ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2232
Preferred Name Subtilisin/kexin type 7
Synonyms LPC | Lymphoma proprotein convertase | PC7 | PC7 | PC8 | PC8 | PCSK7 | Prohormone convertase 7 | Proprotein convertase 7 | Proprotein convertase 8 | Proprotein convertase subtilisin/kexin type 7 | SPC7 | Subtilisin/kexin-like protease PC7 | hPC8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Proprotein convertase subtilisin/kexin type 7 SINGLE PROTEIN Q16549

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160613
Ensembl ENSG00000160613
GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030173 (integral component of Golgi membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0016485 (protein processing)
GO:0016486 (peptide hormone processing)
Wikipedia PCSK7

Target Cross References - Protein

canSAR Q16549
Human Protein Atlas ENSG00000160613
IntAct Q16549
Guide to Pharmacology 2387
Open Targets ENSG00000160613
PharmGKB PA33094
UniProt B0YJ60 Q16549 Q3C1X1 Q53GM4 Q96FK8 Q9UL57

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (PrprotnconvertsP.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Propept_inh.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF16470 (S8_pro-domain)