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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2223
Target Type SINGLE PROTEIN
Preferred Name Gamma-glutamyl hydrolase
Synonyms Conjugase | GGH | GH | Gamma-Glu-X carboxypeptidase | Gamma-glutamyl hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease pcc clan > cysteine protease c26 family

Target Components

Component Description Relationship Accession
Gamma-glutamyl hydrolase SINGLE PROTEIN Q92820

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137563
Ensembl ENSG00000137563
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0005773 (vacuole)
GO:0005829 (cytosol)
GO:0042470 (melanosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008238 (exopeptidase activity)
GO:0008242 (omega peptidase activity)
GO:0034722 (gamma-glutamyl-peptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0006541 (glutamine metabolic process)
GO:0010043 (response to zinc ion)
GO:0032868 (response to insulin)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0046900 (tetrahydrofolylpolyglutamate metabolic process)
Wikipedia GGH_(gene)

Target Cross References - Protein

canSAR Q92820
Human Protein Atlas ENSG00000137563
IntAct Q92820
PharmGKB PA432
UniProt Q92820

Target Cross References - Domain

InterPro IPR011697 (Peptidase_C26.)
IPR015527 (Pept_C26_g-glut_hydrolase.)
IPR029062 (Class_I_gatase-like.)
Pfam PF07722 (Peptidase_C26)

Target Cross References - Structure

PDBe 1L9X
CREDO 1L9X
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