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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2222
Target Type SINGLE PROTEIN
Preferred Name Ornithine carbamoyltransferase
Synonyms OTC | OTCase | Ornithine carbamoyltransferase, mitochondrial | Ornithine transcarbamylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Ornithine carbamoyltransferase, mitochondrial SINGLE PROTEIN P00480

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000036473
Ensembl ENSG00000036473
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0004585 (ornithine carbamoyltransferase activity)
GO:0005543 (phospholipid binding)
GO:0016597 (amino acid binding)
GO:0016740 (transferase activity)
GO:0016743 (carboxyl- or carbamoyltransferase activity)
GO:0042301 (phosphate ion binding)
GO Biological Process GO:0000050 (urea cycle)
GO:0001889 (liver development)
GO:0006520 (cellular amino acid metabolic process)
GO:0006526 (arginine biosynthetic process)
GO:0006591 (ornithine metabolic process)
GO:0006593 (ornithine catabolic process)
GO:0007494 (midgut development)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0010043 (response to zinc ion)
GO:0019240 (citrulline biosynthetic process)
GO:0031667 (response to nutrient levels)
GO:0032868 (response to insulin)
GO:0042450 (arginine biosynthetic process via ornithine)
GO:0042493 (response to drug)
GO:0055081 (anion homeostasis)
GO:0070207 (protein homotrimerization)
GO:0070781 (response to biotin)
GO:0097272 (ammonia homeostasis)
Wikipedia Ornithine_transcarbamylase

Target Cross References - Protein

canSAR P00480
CGD Ornithine transcarbamylase deficiency
Human Protein Atlas ENSG00000036473
Open Targets ENSG00000036473
PharmGKB PA32840
Reactome R-HSA-70635 (Urea cycle.)
UniProt A8K9P2 D3DWB0 P00480 Q3KNR1 Q6B0I1 Q9NYJ5

Target Cross References - Domain

InterPro IPR002292 (Orn/put_carbamltrans.)
IPR006130 (Asp/Orn_carbamoylTrfase.)
IPR006131 (Asp_carbamoyltransf_Asp/Orn-bd.)
IPR006132 (Asp/Orn_carbamoyltranf_P-bd.)
Pfam PF00185 (OTCace)
PF02729 (OTCace_N)

Target Cross References - Structure

PDBe 1C9Y 1EP9 1FVO 1OTH
CREDO 1C9Y 1EP9 1FVO 1OTH
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