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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL222
Target Type SINGLE PROTEIN
Preferred Name Norepinephrine transporter
Synonyms NAT1 | NET | NET1 | Norepinephrine transporter | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter | Solute carrier family 6 member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium-dependent noradrenaline transporter SINGLE PROTEIN P23975

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111346 Serotonin and norepinephrine transporters (SERT/NET) SELECTIVITY GROUP
CHEMBL2096990 Monoamine transporters; Norepinephrine & dopamine SELECTIVITY GROUP
CHEMBL2363064 Monoamine transporter PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL405 AMPHETAMINE Norepinephrine transporter releasing agent 4 KEGG
CHEMBL501 AMPHETAMINE SULFATE Norepinephrine transporter releasing agent 4 KEGG
CHEMBL612 DEXTROAMPHETAMINE Norepinephrine transporter releasing agent 4 PubMed PubMed
CHEMBL796 METHYLPHENIDATE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL904 DEXMETHYLPHENIDATE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL1113 AMOXAPINE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1118 DESVENLAFAXINE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1345 GUANETHIDINE MONOSULFATE Norepinephrine transporter substrate 4 PubMed
CHEMBL1574 PHENTERMINE Norepinephrine transporter releasing agent 4 PubMed
CHEMBL1692 IMIPRAMINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1693 DIETHYLPROPION HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed ISBN PubMed PubMed
CHEMBL1696 DESIPRAMINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1698 BUPROPION HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL1702 ATOMOXETINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed FDA
CHEMBL1722 METHYLPHENIDATE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL1095292 BRETYLIUM TOSYLATE Norepinephrine transporter substrate 4 ISBN PubMed PubMed
CHEMBL1200328 DULOXETINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL1200332 PROTRIPTYLINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 PubMed
CHEMBL1200377 AMPHETAMINE ASPARTATE Norepinephrine transporter releasing agent 4 KEGG
CHEMBL1200387 AMPHETAMINE ADIPATE Norepinephrine transporter releasing agent 4 KEGG
CHEMBL1200395 ORPHENADRINE CITRATE Norepinephrine transporter inhibitor 4 PubMed PubMed
CHEMBL1200483 PHENMETRAZINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 PubMed
CHEMBL1200492 NEFAZODONE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1200594 GUANADREL SULFATE Norepinephrine transporter substrate 4 ISBN PubMed
CHEMBL1200631 IMIPRAMINE PAMOATE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1200695 PHENYLPROPANOLAMINE HYDROCHLORIDE Norepinephrine transporter releasing agent 4 PubMed
CHEMBL1200724 PSEUDOEPHEDRINE HYDROCHLORIDE Norepinephrine transporter releasing agent 4 ISBN PubMed PubMed
CHEMBL1200782 DEXTROAMPHETAMINE ADIPATE Norepinephrine transporter releasing agent 4 PubMed PubMed
CHEMBL1200900 PSEUDOEPHEDRINE SULFATE Norepinephrine transporter releasing agent 4 ISBN PubMed PubMed
CHEMBL1200912 PHENTERMINE HYDROCHLORIDE Norepinephrine transporter releasing agent 4 PubMed
CHEMBL1200948 TRIMIPRAMINE MALEATE Norepinephrine transporter inhibitor 4 ISBN
CHEMBL1200964 AMITRIPTYLINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1200992 DEXTROAMPHETAMINE SACCHARATE Norepinephrine transporter releasing agent 4 PubMed PubMed
CHEMBL1201023 ORPHENADRINE (CHLORIDE) Norepinephrine transporter inhibitor 4 PubMed PubMed
CHEMBL1201066 VENLAFAXINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1201156 NORTRIPTYLINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed FDA
CHEMBL1201178 LISDEXAMFETAMINE DIMESYLATE Norepinephrine transporter releasing agent 4 DailyMed
CHEMBL1201535 PHENYLPROPANOLAMINE POLISTIREX Norepinephrine transporter releasing agent 4 PubMed
CHEMBL1201483 PSEUDOEPHEDRINE POLISTIREX Norepinephrine transporter releasing agent 4 ISBN PubMed PubMed
CHEMBL1201728 DESVENLAFAXINE SUCCINATE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1201735 BUPROPION HYDROBROMIDE Norepinephrine transporter inhibitor 4 DailyMed PubMed
CHEMBL1201777 TAPENTADOL HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1237135 MAPROTILINE HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1628234 DOXEPIN HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL1898523 PHENDIMETRAZINE TARTRATE Norepinephrine transporter inhibitor 4 DailyMed FDA PubMed
CHEMBL2096626 MILNACIPRAN HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL2105732 LEVOMILNACIPRAN HYDROCHLORIDE Norepinephrine transporter inhibitor 4 DailyMed
CHEMBL2110368 BETHANIDINE SULFATE Norepinephrine transporter substrate 4 ISBN PubMed
CHEMBL3039565 DESVENLAFAXINE FUMARATE Norepinephrine transporter inhibitor 4 FDA
CHEMBL3544906 BENZPHETAMINE HYDROCHLORIDE Norepinephrine transporter releasing agent 4 DailyMed PubMed PubMed
CHEMBL3544971 DEXTROAMPHETAMINE SULFATE Norepinephrine transporter releasing agent 4 PubMed PubMed
CHEMBL180101 ESREBOXETINE Norepinephrine transporter inhibitor 3 PubMed
CHEMBL2103857 EDIVOXETINE Norepinephrine transporter inhibitor 3 PubMed
CHEMBL2103829 FAXELADOL Norepinephrine transporter inhibitor 2 PubMed
CHEMBL2104986 TEDATIOXETINE Norepinephrine transporter inhibitor 2 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103546
Ensembl ENSG00000103546
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005330 (dopamine:sodium symporter activity)
GO:0005334 (norepinephrine:sodium symporter activity)
GO:0005515 (protein binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006836 (neurotransmitter transport)
GO:0007268 (chemical synaptic transmission)
GO:0015844 (monoamine transport)
GO:0015874 (norepinephrine transport)
GO:0048265 (response to pain)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0055085 (transmembrane transport)
Wikipedia Norepinephrine_transporter

Target Cross References - Protein

canSAR P23975
CGD Orthostatic intolerance
Human Protein Atlas ENSG00000103546
Guide to Pharmacology 926
Open Targets ENSG00000103546
PharmGKB PA310
Reactome R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
UniProt B2R707 B4DX48 P23975 Q96KH8

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002435 (Na/ntran_symport_noradrenaline.)
Pfam PF00209 (SNF)
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