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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2219
Target Type SINGLE PROTEIN
Preferred Name Protein-tyrosine phosphatase LC-PTP
Synonyms HEPTP | Hematopoietic protein-tyrosine phosphatase | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 7 SINGLE PROTEIN P35236

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143851
Ensembl ENSG00000143851
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0009898 (cytoplasmic side of plasma membrane)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO Biological Process GO:0006470 (protein dephosphorylation)
GO:0016311 (dephosphorylation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0071345 (cellular response to cytokine stimulus)
Wikipedia PTPN7

Target Cross References - Protein

canSAR P35236
Human Protein Atlas ENSG00000143851
IntAct P35236
Open Targets ENSG00000143851
PharmGKB PA34003
Reactome R-HSA-9008059 (Interleukin-37 signaling.)
UniProt B3KXE1 P35236 Q53XK4 Q5SXQ0 Q5SXQ1 Q9BV05

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR008356 (Tyr_Pase_KIM-con.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 1ZC0 2A3K 2GP0 2GPH 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T 3O4U
CREDO 1ZC0 2A3K 2GP0 2GPH 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T 3O4U
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