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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2208
Target Type SINGLE PROTEIN
Preferred Name MAP kinase-activated protein kinase 2
Synonyms MAP kinase-activated protein kinase 2 | MAPK-activated protein kinase 2 | MAPKAP kinase 2 | MAPKAP-K2 | MAPKAPK-2 | MAPKAPK2 | MK-2 | MK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mapkapk family > camk protein kinase mapkapk subfamily

Target Components

Component Description Relationship Accession
MAP kinase-activated protein kinase 2 SINGLE PROTEIN P49137

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3544960 AT-13148 MAP kinase-activated protein kinase 2 inhibitor 1 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162889
Ensembl ENSG00000162889
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0009931 (calcium-dependent protein serine/threonine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0002224 (toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006691 (leukotriene metabolic process)
GO:0006950 (response to stress)
GO:0006954 (inflammatory response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007265 (Ras protein signal transduction)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0031572 (G2 DNA damage checkpoint)
GO:0032496 (response to lipopolysaccharide)
GO:0032675 (regulation of interleukin-6 production)
GO:0032680 (regulation of tumor necrosis factor production)
GO:0034097 (response to cytokine)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038066 (p38MAPK cascade)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0043488 (regulation of mRNA stability)
GO:0044351 (macropinocytosis)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048255 (mRNA stabilization)
GO:0048839 (inner ear development)
GO:0070935 (3'-UTR-mediated mRNA stabilization)
GO:1900034 (regulation of cellular response to heat)
Wikipedia MAPKAPK2

Target Cross References - Protein

canSAR P49137
Human Protein Atlas ENSG00000162889
IntAct P49137
Guide to Pharmacology 2094
Open Targets ENSG00000162889
PharmGKB PA30631
Pharos P49137 (Tchem)
Reactome R-HSA-171007 (p38MAPK events.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450385 (Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.)
R-HSA-450513 (Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.)
UniProt P49137 Q5SY30 Q5SY41 Q8IYD6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR027442 (MAPKAPK_C.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 More...
CREDO 1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 More...
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