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Target Report Card

Target Name and Classification

Target ID CHEMBL2202
Preferred Name Phosphatidylcholine-retinol O-acyltransferase
Synonyms LRAT | Lecithin retinol acyltransferase | Phosphatidylcholine--retinol O-acyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Lecithin retinol acyltransferase SINGLE PROTEIN O95237

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121207
Ensembl ENSG00000121207
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005771 (multivesicular body)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005791 (rough endoplasmic reticulum)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001972 (retinoic acid binding)
GO:0008374 (O-acyltransferase activity)
GO:0016416 (O-palmitoyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0019841 (retinol binding)
GO:0047173 (phosphatidylcholine-retinol O-acyltransferase activity)
GO:0102279 (lecithin:11-cis retinol acyltransferase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006776 (vitamin A metabolic process)
GO:0007601 (visual perception)
GO:0032370 (positive regulation of lipid transport)
GO:0032526 (response to retinoic acid)
GO:0033189 (response to vitamin A)
GO:0042572 (retinol metabolic process)
GO:0050896 (response to stimulus)
GO:1990830 (cellular response to leukemia inhibitory factor)
Wikipedia Lecithin_retinol_acyltransferase

Target Cross References - Protein

canSAR O95237
CGD Leber congenital amaurosis 14; Retinitis pigmentosa, juvenile; Retinal-dystrophy, early-onset severe; Retinitis punctata albescens
Human Protein Atlas ENSG00000121207
Open Targets ENSG00000121207
PharmGKB PA30443
Reactome R-HSA-2453864 (Retinoid cycle disease events.)
R-HSA-2453902 (The canonical retinoid cycle in rods (twilight vision).)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt A8K983 O95237 Q8N716

Target Cross References - Domain

InterPro IPR007053 (LRAT-like_dom.)
Pfam PF04970 (LRAT)