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Target Report Card

Target Name and Classification

Target ID CHEMBL2193
Preferred Name Cerebroside-sulfatase
Synonyms ARSA | ASA | Arylsulfatase A component B | Arylsulfatase A component C | Arylsulfatase A | Cerebroside-sulfatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Arylsulfatase A SINGLE PROTEIN P15289

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100299
Ensembl ENSG00000100299
GO Cellular Component GO:0005576 (extracellular region)
GO:0005764 (lysosome)
GO:0005788 (endoplasmic reticulum lumen)
GO:0035578 (azurophil granule lumen)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004065 (arylsulfatase activity)
GO:0004098 (cerebroside-sulfatase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008484 (sulfuric ester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006687 (glycosphingolipid metabolic process)
GO:0008152 (metabolic process)
GO:0043312 (neutrophil degranulation)
GO:0043687 (post-translational protein modification)
Wikipedia Arylsulfatase_A

Target Cross References - Protein

canSAR P15289
CGD Metachromatic leukodystrophy
Human Protein Atlas ENSG00000100299
IntAct P15289
Open Targets ENSG00000100299
PharmGKB PA25005
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-1663150 (The activation of arylsulfatases.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B2RCA6 B7XD04 F8WCC8 P15289 Q6ICI5 Q96CJ0

Target Cross References - Domain

InterPro IPR000917 (Sulfatase_N.)
IPR017849 (Alkaline_Pase-like_a/b/a.)
IPR017850 (Alkaline_phosphatase_core_sf.)
IPR024607 (Sulfatase_CS.)
Pfam PF00884 (Sulfatase)

Target Cross References - Structure

PDBe 1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
CREDO 1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8