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Target Report Card

Target Name and Classification

Target ID CHEMBL2189147
Target Type SINGLE PROTEIN
Preferred Name Signal transducer and transcription activator 6
Synonyms Signal transducer and transcription activator 6 | Stat6
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and transcription activator 6 SINGLE PROTEIN P52633

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031965 (nuclear membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0019903 (protein phosphatase binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0002296 (T-helper 1 cell lineage commitment)
GO:0002829 (negative regulation of type 2 immune response)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0033598 (mammary gland epithelial cell proliferation)
GO:0034097 (response to cytokine)
GO:0035771 (interleukin-4-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048295 (positive regulation of isotype switching to IgE isotypes)
GO:0060443 (mammary gland morphogenesis)
GO:0070301 (cellular response to hydrogen peroxide)
GO:1902170 (cellular response to reactive nitrogen species)

Target Cross References - Protein

IntAct P52633
Reactome R-MMU-186763 (Downstream signal transduction.)
R-MMU-3249367 (STAT6-mediated induction of chemokines.)
R-MMU-6785807 (Interleukin-4 and 13 signaling.)
UniProt P52633 Q8R2F1

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR012345 (STAT_TF_DNA-bd_N.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
IPR028187 (STAT6_C.)
IPR035857 (STAT6_SH2.)
IPR036535 (STAT_N_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)
PF14596 (STAT6_C)
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