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Target Report Card

Target Name and Classification

Target ID CHEMBL2185
Preferred Name Serine/threonine-protein kinase Aurora-B
Synonyms AIK2 | AIM-1 | AIM1 | AIRK2 | ARK-2 | ARK2 | AURKB | Aurora 1 | Aurora kinase B | Aurora- and IPL1-like midbody-associated protein 1 | Aurora-related kinase 2 | Aurora/IPL1-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase 12 | Serine/threonine-protein kinase 5 | Serine/threonine-protein kinase aurora-B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase aur family

Target Components

Component Description Relationship Accession
Aurora kinase B SINGLE PROTEIN Q96GD4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430907 Aurora kinase B/Inner centromere protein PROTEIN COMPLEX
CHEMBL3430911 Serine/threonine-protein kinase Aurora PROTEIN FAMILY
CHEMBL3883303 Aurora kinase A/B PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL415049 BARASERTIB Serine/threonine-protein kinase Aurora-B inhibitor 3 PubMed
CHEMBL495727 AT-9283 Serine/threonine-protein kinase Aurora-B inhibitor 2 PubMed PubMed
CHEMBL482968 ENMD-2076 Serine/threonine-protein kinase Aurora-B inhibitor 2 Other PubMed PubMed
CHEMBL3545395 BI-811283 Serine/threonine-protein kinase Aurora-B inhibitor 2 Other PubMed
CHEMBL1090479 GSK-1070916 Serine/threonine-protein kinase Aurora-B inhibitor 1 PubMed PubMed
CHEMBL1908397 KW-2449 Serine/threonine-protein kinase Aurora-B inhibitor 1 PubMed PubMed
CHEMBL3544932 TAK-901 Serine/threonine-protein kinase Aurora-B inhibitor 1 PubMed
CHEMBL3545078 PF-03814735 Serine/threonine-protein kinase Aurora-B inhibitor 1 PubMed PubMed
CHEMBL3545428 CHIAURANIB Serine/threonine-protein kinase Aurora-B inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178999
Ensembl ENSG00000178999
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000779 (condensed chromosome, centromeric region)
GO:0000780 (condensed nuclear chromosome, centromeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0010369 (chromocenter)
GO:0030496 (midbody)
GO:0031616 (spindle pole centrosome)
GO:0032133 (chromosome passenger complex)
GO:0051233 (spindle midzone)
GO:1990023 (mitotic spindle midzone)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019900 (kinase binding)
GO:0035174 (histone serine kinase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000278 (mitotic cell cycle)
GO:0002903 (negative regulation of B cell apoptotic process)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007051 (spindle organization)
GO:0007062 (sister chromatid cohesion)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0008608 (attachment of spindle microtubules to kinetochore)
GO:0009838 (abscission)
GO:0016310 (phosphorylation)
GO:0016570 (histone modification)
GO:0016925 (protein sumoylation)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0031577 (spindle checkpoint)
GO:0032091 (negative regulation of protein binding)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032466 (negative regulation of cytokinesis)
GO:0032467 (positive regulation of cytokinesis)
GO:0034501 (protein localization to kinetochore)
GO:0034644 (cellular response to UV)
GO:0036089 (cleavage furrow formation)
GO:0043988 (histone H3-S28 phosphorylation)
GO:0044878 (mitotic cytokinesis checkpoint)
GO:0046777 (protein autophosphorylation)
GO:0051256 (mitotic spindle midzone assembly)
GO:0051301 (cell division)
GO:0051973 (positive regulation of telomerase activity)
GO:0051983 (regulation of chromosome segregation)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904355 (positive regulation of telomere capping)
Wikipedia Aurora_B_kinase

Target Cross References - Protein

Human Protein Atlas ENSG00000178999
IntAct Q96GD4
Guide to Pharmacology 1937
Open Targets ENSG00000178999
PharmGKB PA36199
Pharos Q96GD4 (Tchem)
Reactome R-HSA-141444 (Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.)
R-HSA-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-4615885 (SUMOylation of DNA replication proteins.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-68877 (Mitotic Prometaphase.)
UniProt B4DNM4 C7G533 C7G534 C7G535 D3DTR4 J9JID1 O14630 O60446 O95083 Q96DV5 Q96GD4 Q9UQ46

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028772 (AURKB.)
IPR030616 (Aur.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure