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Target Report Card

Target Name and Classification

Target ID CHEMBL2171
Target Type SINGLE PROTEIN
Preferred Name Dual specificity mitogen-activated protein kinase kinase 6
Synonyms Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK 6 | MEK6 | MKK6 | PRKMK6 | SAPK kinase 3 | SAPKK-3 | SAPKK3 | SKK3 | Stress-activated protein kinase kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 6 SINGLE PROTEIN P52564

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108984
Ensembl ENSG00000108984
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002931 (response to ischemia)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0022602 (ovulation cycle process)
GO:0032308 (positive regulation of prostaglandin secretion)
GO:0035897 (proteolysis in other organism)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0060048 (cardiac muscle contraction)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0072709 (cellular response to sorbitol)
Wikipedia MAP2K6

Target Cross References - Protein

canSAR P52564
Human Protein Atlas ENSG00000108984
IntAct P52564
Guide to Pharmacology 2067
Open Targets ENSG00000108984
PharmGKB PA30591
Pharos P52564 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-375170 (CDO in myogenesis.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
UniProt P52564

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2Y8O 3ENM 3FME 3VN9
CREDO 2Y8O 3ENM 3FME 3VN9
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