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Target Report Card

Target Name and Classification

Target ID CHEMBL217
Target Type SINGLE PROTEIN
Preferred Name Dopamine D2 receptor
Synonyms D(2) dopamine receptor | DRD2 | Dopamine D2 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(2) dopamine receptor SINGLE PROTEIN P14416

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111341 Dopamine D1 and D2 receptor SELECTIVITY GROUP
CHEMBL3038478 Dopamine receptor D2L/neurotensin receptor NTS1 PROTEIN COMPLEX
CHEMBL2095169 Dopamine receptors; D2 & D3 SELECTIVITY GROUP
CHEMBL2111468 Dopamine D2 receptor and serotonin 2a receptor SELECTIVITY GROUP
CHEMBL2095396 Dopamine receptors; D2 & D4 SELECTIVITY GROUP
CHEMBL2331075 D2-like dopamine receptor PROTEIN FAMILY
CHEMBL2111460 Dopamine D2 receptor and serotonin 1a receptor SELECTIVITY GROUP
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL42 CLOZAPINE Dopamine D2 receptor antagonist 4 DailyMed ISBN PubMed
CHEMBL85 RISPERIDONE Dopamine D2 receptor antagonist 4 DailyMed FDA
CHEMBL14376 ILOPERIDONE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL567 PERPHENAZINE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL570 TRIFLUPROMAZINE Dopamine D2 receptor antagonist 4 KEGG Other PubMed PubMed PubMed
CHEMBL728 PROCHLORPERAZINE Dopamine D2 receptor antagonist 4 DailyMed ISBN
CHEMBL908 CHLORPROTHIXENE Dopamine D2 receptor antagonist 4 PubMed PubMed
CHEMBL1112 ARIPIPRAZOLE Dopamine D2 receptor partial agonist 4 DailyMed
CHEMBL1201 THIOTHIXENE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL1621 PALIPERIDONE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL1712 ZIPRASIDONE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL1200419 MOLINDONE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed
CHEMBL1200587 PROCHLORPERAZINE MALEATE Dopamine D2 receptor antagonist 4 DailyMed ISBN
CHEMBL1200707 BENZQUINAMIDE HYDROCHLORIDE Dopamine D2 receptor modulator 4 PubMed PubMed
CHEMBL1200792 FLUPHENAZINE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed
CHEMBL1200854 FLUPHENAZINE DECANOATE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed
CHEMBL1200856 THIETHYLPERAZINE MALEATE Dopamine D2 receptor antagonist 4 ISBN PubMed
CHEMBL1200902 THIOTHIXENE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL1200911 QUETIAPINE FUMARATE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL1200940 METOCLOPRAMIDE HYDROCHLORIDE HYDRATE Dopamine D2 receptor antagonist 4 DailyMed FDA
CHEMBL1200948 TRIMIPRAMINE MALEATE Dopamine D2 receptor antagonist 4 ISBN
CHEMBL1200951 FLUPHENAZINE ENANTHATE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed
CHEMBL1200997 ZIPRASIDONE MESYLATE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL1201052 MESORIDAZINE BESYLATE Dopamine D2 receptor antagonist 4 PubMed PubMed PubMed
CHEMBL1201074 THIETHYLPERAZINE MALATE Dopamine D2 receptor antagonist 4 ISBN PubMed
CHEMBL1201087 CABERGOLINE Dopamine D2 receptor agonist 4 DailyMed FDA
CHEMBL1201102 TRIFLUPROMAZINE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 KEGG Other PubMed PubMed PubMed
CHEMBL1201154 PROCHLORPERAZINE EDISYLATE Dopamine D2 receptor antagonist 4 DailyMed FDA
CHEMBL1201732 PALIPERIDONE PALMITATE Dopamine D2 receptor antagonist 4 FDA
CHEMBL1615372 LURASIDONE HYDROCHLORIDE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL2024517 CARIPRAZINE HYDROCHLORIDE Dopamine D2 receptor modulator 4 DailyMed PubMed
CHEMBL2105760 BREXPIPRAZOLE Dopamine D2 receptor partial agonist 4 FDA
CHEMBL2219425 ARIPIPRAZOLE LAUROXIL Dopamine D2 receptor partial agonist 4 DailyMed
CHEMBL2358147 CARPHENAZINE MALEATE Dopamine D2 receptor antagonist 4 ISBN PubMed
CHEMBL2360079 ACETOPHENAZINE MALEATE Dopamine D2 receptor antagonist 4 PubMed PubMed
CHEMBL3544974 ASENAPINE MALEATE Dopamine D2 receptor antagonist 4 DailyMed
CHEMBL218166 BIFEPRUNOX Dopamine D2 receptor partial agonist 3 PubMed
CHEMBL596802 PRIDOPIDINE Dopamine D2 receptor modulator 3 PubMed PubMed
CHEMBL2146110 SARIZOTAN HYDROCHLORIDE Dopamine D2 receptor partial agonist 3 PubMed PubMed
CHEMBL3545044 ITI-007 Dopamine D2 receptor partial agonist 3 Other PubMed PubMed
CHEMBL2104864 APLINDORE FUMARATE Dopamine D2 receptor partial agonist 2 PubMed
CHEMBL3545102 SB-773812 Dopamine D2 receptor antagonist 2 PubMed
CHEMBL3545010 Ordopidine Dopamine D2 receptor modulator 1 Other PubMed
CHEMBL3545388 Seridopidine Dopamine D2 receptor modulator 1 Other PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149295
Ensembl ENSG00000149295
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005622 (intracellular)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016328 (lateral plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030672 (synaptic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031513 (nonmotile primary cilium)
GO:0036126 (sperm flagellum)
GO:0043197 (dendritic spine)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0060170 (ciliary membrane)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0015459 (potassium channel regulator activity)
GO:0035240 (dopamine binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001666 (response to hypoxia)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001964 (startle response)
GO:0001975 (response to amphetamine)
GO:0001976 (neurological system process involved in regulation of systemic arterial blood pressure)
GO:0002027 (regulation of heart rate)
GO:0002028 (regulation of sodium ion transport)
GO:0002031 (G-protein coupled receptor internalization)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002092 (positive regulation of receptor internalization)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007270 (neuron-neuron synaptic transmission)
GO:0007409 (axonogenesis)
GO:0007416 (synapse assembly)
GO:0007608 (sensory perception of smell)
GO:0007616 (long-term memory)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008104 (protein localization)
GO:0008285 (negative regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0009416 (response to light stimulus)
GO:0009636 (response to toxic substance)
GO:0010039 (response to iron ion)
GO:0014059 (regulation of dopamine secretion)
GO:0014854 (response to inactivity)
GO:0016055 (Wnt signaling pathway)
GO:0021756 (striatum development)
GO:0021769 (orbitofrontal cortex development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0021984 (adenohypophysis development)
GO:0030336 (negative regulation of cell migration)
GO:0030432 (peristalsis)
GO:0030534 (adult behavior)
GO:0030814 (regulation of cAMP metabolic process)
GO:0030900 (forebrain development)
GO:0031223 (auditory behavior)
GO:0032147 (activation of protein kinase activity)
GO:0032228 (regulation of synaptic transmission, GABAergic)
GO:0032467 (positive regulation of cytokinesis)
GO:0032922 (circadian regulation of gene expression)
GO:0033602 (negative regulation of dopamine secretion)
GO:0034776 (response to histamine)
GO:0035094 (response to nicotine)
GO:0035556 (intracellular signal transduction)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042220 (response to cocaine)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0043266 (regulation of potassium ion transport)
GO:0043278 (response to morphine)
GO:0043408 (regulation of MAPK cascade)
GO:0043473 (pigmentation)
GO:0043666 (regulation of phosphoprotein phosphatase activity)
GO:0045471 (response to ethanol)
GO:0045745 (positive regulation of G-protein coupled receptor protein signaling pathway)
GO:0045776 (negative regulation of blood pressure)
GO:0045824 (negative regulation of innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046676 (negative regulation of insulin secretion)
GO:0046717 (acid secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048149 (behavioral response to ethanol)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048678 (response to axon injury)
GO:0048755 (branching morphogenesis of a nerve)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050804 (modulation of synaptic transmission)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051584 (regulation of dopamine uptake involved in synaptic transmission)
GO:0051586 (positive regulation of dopamine uptake involved in synaptic transmission)
GO:0051823 (regulation of synapse structural plasticity)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060124 (positive regulation of growth hormone secretion)
GO:0060134 (prepulse inhibition)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060160 (negative regulation of dopamine receptor signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090325 (regulation of locomotion involved in locomotory behavior)
GO:0099565 (chemical synaptic transmission, postsynaptic)
GO:1900168 (positive regulation of glial cell-derived neurotrophic factor secretion)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
Wikipedia Dopamine_receptor_D2

Target Cross References - Protein

canSAR P14416
CGD Myoclonic dystonia
Human Protein Atlas ENSG00000149295
IntAct P14416
Guide to Pharmacology 215
MICAD NBK23195 (D2 dopamine receptors)
Open Targets ENSG00000149295
PharmGKB PA27478
Pharos P14416 (Tclin)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P14416 Q9NZR3 Q9UPA9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001922 (Dopamine_D2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5AER
CREDO 5AER
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