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Target Report Card

Target Name and Classification

Target ID CHEMBL2161
Preferred Name Glutathione transferase omega 2
Synonyms GSTO 2-2 | GSTO-2 | GSTO2 | Glutathione S-transferase omega 2-2 | Glutathione S-transferase omega-2 | Glutathione-dependent dehydroascorbate reductase | MMA(V) reductase | Monomethylarsonic acid reductase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase omega-2 SINGLE PROTEIN Q9H4Y5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065621
Ensembl ENSG00000065621
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016740 (transferase activity)
GO:0045174 (glutathione dehydrogenase (ascorbate) activity)
GO:0050610 (methylarsonate reductase activity)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008152 (metabolic process)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia GSTO2

Target Cross References - Protein

canSAR Q9H4Y5
Human Protein Atlas ENSG00000065621
IntAct Q9H4Y5
Open Targets ENSG00000065621
PharmGKB PA133787053
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-196836 (Vitamin C (ascorbate) metabolism.)
UniProt A8K771 B4DJW6 E7ESD6 Q49TW5 Q5GM70 Q5JU15 Q86WP3 Q9H4Y5

Target Cross References - Domain

InterPro IPR004045 (Glutathione_S-Trfase_N.)
IPR005442 (GST_omega.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR012336 (Thioredoxin-like_fold.)
Pfam PF13417 (GST_N_3)

Target Cross References - Structure

PDBe 3Q18 3Q19 3QAG
CREDO 3Q18 3Q19 3QAG