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Target Report Card

Target Name and Classification

Target ID CHEMBL2160
Target Type SINGLE PROTEIN
Preferred Name Nucleoside diphosphate kinase 2
Synonyms C-myc purine-binding transcription factor PUF | Histidine protein kinase NDKB | NDK B | NDP kinase B | NM23B | NME2 | Nucleoside diphosphate kinase B | nm23-H2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nucleoside diphosphate kinase B SINGLE PROTEIN P22392

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000243678
Ensembl ENSG00000243678
GO Cellular Component GO:0001726 (ruffle)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0030027 (lamellipodium)
GO:0034774 (secretory granule lumen)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO:0071944 (cell periphery)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004550 (nucleoside diphosphate kinase activity)
GO:0004673 (protein histidine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006165 (nucleoside diphosphate phosphorylation)
GO:0006183 (GTP biosynthetic process)
GO:0006228 (UTP biosynthetic process)
GO:0006241 (CTP biosynthetic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007155 (cell adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0009117 (nucleotide metabolic process)
GO:0009142 (nucleoside triphosphate biosynthetic process)
GO:0015949 (nucleobase-containing small molecule interconversion)
GO:0016310 (phosphorylation)
GO:0018106 (peptidyl-histidine phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0045618 (positive regulation of keratinocyte differentiation)
GO:0045682 (regulation of epidermis development)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050679 (positive regulation of epithelial cell proliferation)
Wikipedia NME2

Target Cross References - Protein

canSAR P22392
Human Protein Atlas ENSG00000243678
IntAct P22392
Open Targets ENSG00000243678
PharmGKB PA162398077
Reactome R-HSA-499943 (Interconversion of nucleotide di- and triphosphates.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8MWA3 P22392 Q1WM23 Q6LCT6

Target Cross References - Domain

InterPro IPR001564 (Nucleoside_diP_kinase.)
IPR023005 (Nucleoside_diP_kinase_AS.)
IPR034907 (NDK-like_dom.)
IPR036850 (NDK-like_dom_sf.)
Pfam PF00334 (NDK)

Target Cross References - Structure

PDBe 1NSK 1NUE 3BBB 3BBC 3BBF
CREDO 1NSK 1NUE 3BBB 3BBC 3BBF
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