ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2157
Preferred Name Interleukin-8
Synonyms (Ala-IL-8)77 | (Ser-IL-8)72 | C-X-C motif chemokine 8 | CXCL8 | Chemokine (C-X-C motif) ligand 8 | Emoctakin | GCP-1 | GCP/IL-8 protein I | GCP/IL-8 protein II | GCP/IL-8 protein III | GCP/IL-8 protein IV | GCP/IL-8 protein V | GCP/IL-8 protein VI | Granulocyte chemotactic protein 1 | IL-8 | IL-8(1-77) | IL-8(5-77) | IL-8(6-77) | IL-8(7-77) | IL-8(8-77) | IL-8(9-77) | IL8 | IL8/NAP1 form I | IL8/NAP1 form II | IL8/NAP1 form III | IL8/NAP1 form IV | IL8/NAP1 form V | IL8/NAP1 form VI | Interleukin-8 | LYNAP | Lymphocyte-derived neutrophil-activating factor | MDNCF | MDNCF-a | MDNCF-b | MDNCF-c | MONAP | Monocyte-derived neutrophil chemotactic factor | Monocyte-derived neutrophil-activating peptide | NAF | NAP-1 | Neutrophil-activating factor | Neutrophil-activating protein 1 | Protein 3-10C | T-cell chemotactic factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Interleukin-8 SINGLE PROTEIN P10145

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109616 ABX-IL8 Interleukin-8 inhibitor 2 PubMed
CHEMBL2109617 HUMAX-IL8 Interleukin-8 inhibitor 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169429
Ensembl ENSG00000169429
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005153 (interleukin-8 receptor binding)
GO:0005515 (protein binding)
GO:0008009 (chemokine activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002237 (response to molecule of bacterial origin)
GO:0006935 (chemotaxis)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0010469 (regulation of receptor activity)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019722 (calcium-mediated signaling)
GO:0030155 (regulation of cell adhesion)
GO:0030593 (neutrophil chemotaxis)
GO:0031623 (receptor internalization)
GO:0031640 (killing of cells of other organism)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035556 (intracellular signal transduction)
GO:0036499 (PERK-mediated unfolded protein response)
GO:0042119 (neutrophil activation)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045091 (regulation of single stranded viral RNA replication via double stranded DNA intermediate)
GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
GO:0045766 (positive regulation of angiogenesis)
GO:0048566 (embryonic digestive tract development)
GO:0050930 (induction of positive chemotaxis)
GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:2000535 (regulation of entry of bacterium into host cell)
Wikipedia Interleukin_8

Target Cross References - Protein

canSAR P10145
Human Protein Atlas ENSG00000169429
IntAct P10145
Open Targets ENSG00000169429
PharmGKB PA29841
Reactome R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-380994 (ATF4 activates genes.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B2R4L8 P10145 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0

Target Cross References - Domain

InterPro IPR001089 (Chemokine_CXC.)
IPR001811 (Chemokine_IL8-like_dom.)
IPR018048 (Chemokine_CXC_CS.)
IPR028469 (Interleukin-8.)
IPR033899 (CXC_Chemokine_domain.)
IPR036048 (Interleukin_8-like_sf.)
Pfam PF00048 (IL8)

Target Cross References - Structure

PDBe 1ICW 1QE6 3IL8 4XDX 5D14