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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2157
Target Type SINGLE PROTEIN
Preferred Name Interleukin-8
Synonyms (Ala-IL-8)77 | (Ser-IL-8)72 | C-X-C motif chemokine 8 | CXCL8 | Chemokine (C-X-C motif) ligand 8 | Emoctakin | GCP-1 | GCP/IL-8 protein I | GCP/IL-8 protein II | GCP/IL-8 protein III | GCP/IL-8 protein IV | GCP/IL-8 protein V | GCP/IL-8 protein VI | Granulocyte chemotactic protein 1 | IL-8 | IL-8(1-77) | IL-8(5-77) | IL-8(6-77) | IL-8(7-77) | IL-8(8-77) | IL-8(9-77) | IL8 | IL8/NAP1 form I | IL8/NAP1 form II | IL8/NAP1 form III | IL8/NAP1 form IV | IL8/NAP1 form V | IL8/NAP1 form VI | Interleukin-8 | LYNAP | Lymphocyte-derived neutrophil-activating factor | MDNCF | MDNCF-a | MDNCF-b | MDNCF-c | MONAP | Monocyte-derived neutrophil chemotactic factor | Monocyte-derived neutrophil-activating peptide | NAF | NAP-1 | Neutrophil-activating factor | Neutrophil-activating protein 1 | Protein 3-10C | T-cell chemotactic factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Interleukin-8 SINGLE PROTEIN P10145

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169429
Ensembl ENSG00000169429
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0005153 (interleukin-8 receptor binding)
GO:0008009 (chemokine activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007050 (cell cycle arrest)
GO:0007186 (G-protein coupled receptor protein signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0019722 (calcium-mediated signaling)
GO:0030155 (regulation of cell adhesion)
GO:0030593 (neutrophil chemotaxis)
GO:0042119 (neutrophil activation)
GO:0045091 (regulation of retroviral genome replication)
GO:0048566 (embryonic digestive tract development)
GO:0050930 (induction of positive chemotaxis)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0090023 (positive regulation of neutrophil chemotaxis)
Wikipedia Interleukin_8

Target Cross References - Protein

canSAR P10145
Human Protein Atlas ENSG00000169429
PharmGKB PA29841
Reactome REACT_14797 (Signaling by GPCR.)
REACT_15380 (Diabetes pathways.)
UniProt B2R4L8 P10145 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0

Target Cross References - Domain

InterPro IPR001089 (Chemokine_CXC.)
IPR001811 (Chemokine_IL8-like_dom.)
IPR002473 (Chemokine_CXCL8/IL8.)
IPR018048 (Chemokine_CXC_CS.)
Pfam PF00048 (IL8)

Target Cross References - Structure

PDBe 1ICW 1QE6 3IL8
CREDO 1ICW 1QE6 3IL8
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