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Target Report Card

Target Name and Classification

Target ID CHEMBL2148
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase JAK3
Synonyms JAK-3 | JAK3 | Janus kinase 3 | L-JAK | Leukocyte janus kinase | Tyrosine-protein kinase JAK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jakb family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jaka family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase JAK3 SINGLE PROTEIN P52333

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363062 Janus Kinase (JAK) PROTEIN FAMILY
CHEMBL3038491 JAK3/JAK1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL495727 AT-9283 Tyrosine-protein kinase JAK3 inhibitor 2 PubMed PubMed
CHEMBL3039513 DECERNOTINIB Tyrosine-protein kinase JAK3 inhibitor 2 PubMed
CHEMBL3545159 R-333 Tyrosine-protein kinase JAK3 inhibitor 2 Other
CHEMBL3545284 Cerdulatinib Tyrosine-protein kinase JAK3 inhibitor 2 Other PubMed
CHEMBL3545382 R-348 Tyrosine-protein kinase JAK3 inhibitor 2 PubMed PubMed
CHEMBL405130 WHI-P131 Tyrosine-protein kinase JAK3 inhibitor 1 PubMed
CHEMBL2106468 TRICETAMIDE Tyrosine-protein kinase JAK3 inhibitor 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105639
Ensembl ENSG00000105639
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002731 (negative regulation of dendritic cell cytokine production)
GO:0006468 (protein phosphorylation)
GO:0007167 (enzyme linked receptor protein signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0007262 (STAT protein import into nucleus)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030183 (B cell differentiation)
GO:0032693 (negative regulation of interleukin-10 production)
GO:0032695 (negative regulation of interleukin-12 production)
GO:0035556 (intracellular signal transduction)
GO:0035771 (interleukin-4-mediated signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042506 (tyrosine phosphorylation of Stat5 protein)
GO:0043029 (T cell homeostasis)
GO:0043547 (positive regulation of GTPase activity)
GO:0045087 (innate immune response)
GO:0045221 (negative regulation of FasL biosynthetic process)
GO:0045626 (negative regulation of T-helper 1 cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0050778 (positive regulation of immune response)
GO:0050868 (negative regulation of T cell activation)
GO:0051928 (positive regulation of calcium ion transport)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0070232 (regulation of T cell apoptotic process)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0070669 (response to interleukin-2)
GO:0070670 (response to interleukin-4)
GO:0070672 (response to interleukin-15)
GO:0071104 (response to interleukin-9)
Wikipedia Janus_kinase_3

Target Cross References - Protein

canSAR P52333
CGD Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, natural killer cell-negative
Human Protein Atlas ENSG00000105639
IntAct P52333
Guide to Pharmacology 2049
Open Targets ENSG00000105639
PharmGKB PA29990
Pharos P52333 (Tclin)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1266695 (Interleukin-7 signaling.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
UniProt P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR016251 (Tyr_kinase_non-rcpt_Jak/Tyk2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020775 (Tyr_kinase_non-rcpt_Jak3.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ
CREDO 1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ
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