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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2148
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase JAK3
Synonyms JAK-3 | JAK3 | Janus kinase 3 | L-JAK | Leukocyte janus kinase | Tyrosine-protein kinase JAK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jaka family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jakb family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase JAK3 SINGLE PROTEIN P52333

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038491 JAK3/JAK1 PROTEIN COMPLEX
CHEMBL2363062 Janus Kinase (JAK) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105639
Ensembl ENSG00000105639
GO Cellular Component GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO Molecular Function GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0002731 (negative regulation of dendritic cell cytokine production)
GO:0007167 (enzyme linked receptor protein signaling pathway)
GO:0007243 (intracellular protein kinase cascade)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030183 (B cell differentiation)
GO:0032693 (negative regulation of interleukin-10 production)
GO:0032695 (negative regulation of interleukin-12 production)
GO:0043029 (T cell homeostasis)
GO:0045221 (negative regulation of FasL biosynthetic process)
GO:0045626 (negative regulation of T-helper 1 cell differentiation)
GO:0045768 (positive regulation of anti-apoptosis)
GO:0070244 (negative regulation of thymocyte apoptosis)
GO:0070669 (response to interleukin-2)
GO:0070670 (response to interleukin-4)
GO:0070672 (response to interleukin-15)
GO:0071104 (response to interleukin-9)
Wikipedia Janus_kinase_3

Target Cross References - Protein

canSAR P52333
CGD Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, natural killer cell-negative
Human Protein Atlas ENSG00000105639
IntAct P52333
PharmGKB PA29990
Reactome REACT_6900 (Signaling in Immune system.)
UniProt P52333 Q13259 Q13260 Q13611 Q99699 Q9Y6S2

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016251 (Tyr_kinase_non-rcpt_Jak/Tyk2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020775 (Tyr_kinase_non-rcpt_Jak3.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1YVJ 3LXK 3LXL 3PJC
CREDO 1YVJ 3LXK 3LXL 3PJC
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