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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2147
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PIM1
Synonyms PIM1 | Serine/threonine-protein kinase pim-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase pim family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase pim-1 SINGLE PROTEIN P11309

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137193
Ensembl ENSG00000137193
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0030145 (manganese ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007275 (multicellular organismal development)
GO:0008283 (cell proliferation)
GO:0031659 (positive regulation of cyclin-dependent protein kinase activity involved in G1/S)
GO:0043066 (negative regulation of apoptosis)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0046777 (protein autophosphorylation)
Wikipedia PIM1

Target Cross References - Protein

canSAR P11309
Human Protein Atlas ENSG00000137193
IntAct P11309
Guide to Pharmacology 2158 (Pim-1 proto-oncogene, serine/threonine kinase)
PharmGKB PA33318
UniProt P11309 Q38RT9 Q5T7H7 Q96RG3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017348 (STPK_Pim-1.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 More...
CREDO 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 More...
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