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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2136
Target Type SINGLE PROTEIN
Preferred Name Pepsinogen C
Synonyms Gastricsin | PGC | Pepsinogen C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession
Gastricsin SINGLE PROTEIN P20142

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096088
Ensembl ENSG00000096088
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002803 (positive regulation of antibacterial peptide production)
GO:0006508 (proteolysis)
GO:0007586 (digestion)
GO:0030163 (protein catabolic process)
Wikipedia Gastricsin

Target Cross References - Protein

canSAR P20142
Human Protein Atlas ENSG00000096088
Guide to Pharmacology 2391
Open Targets ENSG00000096088
PharmGKB PA33228
UniProt B4DVZ3 P20142 Q5T3D7 Q5T3D8

Target Cross References - Domain

InterPro IPR001461 (Aspartic_peptidase_A1.)
IPR001969 (Aspartic_peptidase_AS.)
IPR012848 (Aspartic_peptidase_N.)
IPR021109 (Peptidase_aspartic_dom.)
IPR033121 (PEPTIDASE_A1.)
IPR033735 (Gastricsin.)
Pfam PF00026 (Asp)
PF07966 (A1_Propeptide)

Target Cross References - Structure

PDBe 1AVF 1HTR
CREDO 1AVF 1HTR
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