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Target Report Card

Target Name and Classification

Target ID CHEMBL2127
Target Type SINGLE PROTEIN
Preferred Name Hepatic lipase
Synonyms HL | HTGL | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | Lipase member C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hepatic triacylglycerol lipase SINGLE PROTEIN P11150

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166035
Ensembl ENSG00000166035
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005902 (microvillus)
GO:0009986 (cell surface)
GO:0034364 (high-density lipoprotein particle)
GO Molecular Function GO:0004620 (phospholipase activity)
GO:0004622 (lysophospholipase activity)
GO:0004806 (triglyceride lipase activity)
GO:0008201 (heparin binding)
GO:0008289 (lipid binding)
GO:0008970 (phosphatidylcholine 1-acylhydrolase activity)
GO:0016298 (lipase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0016787 (hydrolase activity)
GO:0030169 (low-density lipoprotein particle binding)
GO:0034185 (apolipoprotein binding)
GO:0043395 (heparan sulfate proteoglycan binding)
GO:0047372 (acylglycerol lipase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006641 (triglyceride metabolic process)
GO:0006658 (phosphatidylserine metabolic process)
GO:0007623 (circadian rhythm)
GO:0008203 (cholesterol metabolic process)
GO:0009725 (response to hormone)
GO:0009743 (response to carbohydrate)
GO:0010034 (response to acetate)
GO:0010035 (response to inorganic substance)
GO:0014070 (response to organic cyclic compound)
GO:0015012 (heparan sulfate proteoglycan biosynthetic process)
GO:0016042 (lipid catabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0030301 (cholesterol transport)
GO:0031667 (response to nutrient levels)
GO:0032026 (response to magnesium ion)
GO:0032870 (cellular response to hormone stimulus)
GO:0033993 (response to lipid)
GO:0034371 (chylomicron remodeling)
GO:0034372 (very-low-density lipoprotein particle remodeling)
GO:0034373 (intermediate-density lipoprotein particle remodeling)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0034382 (chylomicron remnant clearance)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0034638 (phosphatidylcholine catabolic process)
GO:0042493 (response to drug)
GO:0042632 (cholesterol homeostasis)
GO:0043200 (response to amino acid)
GO:0043434 (response to peptide hormone)
GO:0043691 (reverse cholesterol transport)
GO:0044241 (lipid digestion)
GO:0046337 (phosphatidylethanolamine metabolic process)
GO:0046461 (neutral lipid catabolic process)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0046473 (phosphatidic acid metabolic process)
GO:0046475 (glycerophospholipid catabolic process)
GO:0046688 (response to copper ion)
GO:0048589 (developmental growth)
GO:0051259 (protein oligomerization)
GO:0051384 (response to glucocorticoid)
GO:0051592 (response to calcium ion)
GO:0070328 (triglyceride homeostasis)
GO:0070542 (response to fatty acid)
GO:0097006 (regulation of plasma lipoprotein particle levels)
Wikipedia Hepatic_lipase

Target Cross References - Protein

CGD Hepatic lipase deficiency
Human Protein Atlas ENSG00000166035
IntAct P11150
Open Targets ENSG00000166035
PharmGKB PA230
Reactome R-HSA-174800 (Chylomicron-mediated lipid transport.)
R-HSA-192456 (Digestion of dietary lipid.)
UniProt A2RUB4 A8K9B6 O43571 P11150 P78529 Q99465

Target Cross References - Domain

InterPro IPR000734 (TAG_lipase.)
IPR001024 (PLAT/LH2_dom.)
IPR002333 (Lipase_hep.)
IPR013818 (Lipase/vitellogenin.)
IPR016272 (Lipase_LIPH.)
IPR029058 (AB_hydrolase.)
IPR033906 (Lipase_N.)
Pfam PF00151 (Lipase)
PF01477 (PLAT)
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