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Target Report Card

Target Name and Classification

Target ID CHEMBL2127
Preferred Name Hepatic lipase
Synonyms HTGL | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | Lipase member C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hepatic triacylglycerol lipase SINGLE PROTEIN P11150

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166035
Ensembl ENSG00000166035
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0034364 (high-density lipoprotein particle)
GO Molecular Function GO:0004620 (phospholipase activity)
GO:0004806 (triglyceride lipase activity)
GO:0008201 (heparin binding)
GO:0016298 (lipase activity)
GO:0016787 (hydrolase activity)
GO:0030169 (low-density lipoprotein particle binding)
GO:0034185 (apolipoprotein binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0008203 (cholesterol metabolic process)
GO:0016042 (lipid catabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0030301 (cholesterol transport)
GO:0034372 (very-low-density lipoprotein particle remodeling)
GO:0034373 (intermediate-density lipoprotein particle remodeling)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0034382 (chylomicron remnant clearance)
GO:0034638 (phosphatidylcholine catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0043691 (reverse cholesterol transport)
GO:0051004 (regulation of lipoprotein lipase activity)
GO:0070328 (triglyceride homeostasis)
Wikipedia Hepatic_lipase

Target Cross References - Protein

CGD Hepatic lipase deficiency
Human Protein Atlas ENSG00000166035
IntAct P11150
Open Targets ENSG00000166035
PharmGKB PA230
Reactome R-HSA-8963889 (Assembly of active LPL and LIPC lipase complexes.)
R-HSA-8964026 (Chylomicron clearance.)
UniProt A2RUB4 A8K9B6 O43571 P11150 P78529 Q99465

Target Cross References - Domain

InterPro IPR000734 (TAG_lipase.)
IPR001024 (PLAT/LH2_dom.)
IPR002333 (Lipase_hep.)
IPR013818 (Lipase/vitellogenin.)
IPR016272 (Lipase_LIPH.)
IPR029058 (AB_hydrolase.)
IPR033906 (Lipase_N.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00151 (Lipase)
PF01477 (PLAT)