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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2121
Target Type SINGLE PROTEIN
Preferred Name Folate receptor alpha
Synonyms Adult folate-binding protein | FBP | FOLR | FOLR1 | FR-alpha | Folate receptor 1 | Folate receptor alpha | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Folate receptor alpha SINGLE PROTEIN P15328

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743016 FARLETUZUMAB Folate receptor alpha inhibitor 3 PubMed
CHEMBL3039521 VINTAFOLIDE Folate receptor alpha binding agent 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110195
Ensembl ENSG00000110195
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005768 (endosome)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005903 (brush border)
GO:0009986 (cell surface)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030136 (clathrin-coated vesicle)
GO:0031225 (anchored component of membrane)
GO:0031362 (anchored component of external side of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031526 (brush border membrane)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:0046658 (anchored component of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004872 (receptor activity)
GO:0005542 (folic acid binding)
GO:0008144 (drug binding)
GO:0008517 (folic acid transporter activity)
GO:0051870 (methotrexate binding)
GO:0061714 (folic acid receptor activity)
GO Biological Process GO:0001947 (heart looping)
GO:0003147 (neural crest cell migration involved in heart formation)
GO:0003253 (cardiac neural crest cell migration involved in outflow tract morphogenesis)
GO:0006810 (transport)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0015884 (folic acid transport)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0031103 (axon regeneration)
GO:0046655 (folic acid metabolic process)
GO:0048208 (COPII vesicle coating)
GO:0048678 (response to axon injury)
GO:0060828 (regulation of canonical Wnt signaling pathway)
GO:0061626 (pharyngeal arch artery morphogenesis)
GO:0061713 (anterior neural tube closure)
GO:0071231 (cellular response to folic acid)
Wikipedia Folate_receptor_1

Target Cross References - Protein

canSAR P15328
CGD Cerebral folate deficiency
Human Protein Atlas ENSG00000110195
IntAct P15328
Open Targets ENSG00000110195
PharmGKB PA28207
Reactome R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-5694530 (Cargo concentration in the ER.)
R-HSA-6807878 (COPI-mediated anterograde transport.)
UniProt P15328 Q53EW2 Q6FGT8 Q6LC90 Q9UCT2

Target Cross References - Domain

InterPro IPR004269 (Folate_rcpt.)
IPR018143 (Folate_rcpt-like.)
IPR032935 (FOLR1.)
Pfam PF03024 (Folate_rec)

Target Cross References - Structure

PDBe 4KM6 4KM7 4KMX 4LRH 5IZQ
CREDO 4KM6 4KM7 4KMX 4LRH 5IZQ
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