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Target Report Card

Target Name and Classification

Target ID CHEMBL2120
Target Type SINGLE PROTEIN
Preferred Name Acidic fibroblast growth factor
Synonyms Acidic fibroblast growth factor | ECGF | Endothelial cell growth factor | FGF-1 | FGF1 | FGFA | Fibroblast growth factor 1 | HBGF-1 | Heparin-binding growth factor 1 | aFGF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Fibroblast growth factor 1 SINGLE PROTEIN P05230

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113578
Ensembl ENSG00000113578
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005938 (cell cortex)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005104 (fibroblast growth factor receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008201 (heparin binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0030544 (Hsp70 protein binding)
GO:0044548 (S100 protein binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0001525 (angiogenesis)
GO:0001759 (organ induction)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009653 (anatomical structure morphogenesis)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030335 (positive regulation of cell migration)
GO:0032148 (activation of protein kinase B activity)
GO:0034605 (cellular response to heat)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0045542 (positive regulation of cholesterol biosynthetic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051781 (positive regulation of cell division)
GO:0060681 (branch elongation involved in ureteric bud branching)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0072163 (mesonephric epithelium development)
GO:1901509 (regulation of endothelial tube morphogenesis)
GO:1902533 (positive regulation of intracellular signal transduction)
GO:1903672 (positive regulation of sprouting angiogenesis)
GO:2000544 (regulation of endothelial cell chemotaxis to fibroblast growth factor)
Wikipedia FGF1

Target Cross References - Protein

canSAR P05230
Human Protein Atlas ENSG00000113578
IntAct P05230
Open Targets ENSG00000113578
PharmGKB PA28105
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1839122 (Signaling by activated point mutants of FGFR1.)
R-HSA-1839130 (Signaling by activated point mutants of FGFR3.)
R-HSA-190322 (FGFR4 ligand binding and activation.)
R-HSA-190370 (FGFR1b ligand binding and activation.)
R-HSA-190371 (FGFR3b ligand binding and activation.)
R-HSA-190372 (FGFR3c ligand binding and activation.)
R-HSA-190373 (FGFR1c ligand binding and activation.)
R-HSA-190375 (FGFR2c ligand binding and activation.)
R-HSA-190377 (FGFR2b ligand binding and activation.)
R-HSA-2033514 (FGFR3 mutant receptor activation.)
R-HSA-2033519 (Activated point mutants of FGFR2.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5654219 (Phospholipase C-mediated cascade: FGFR1.)
R-HSA-5654221 (Phospholipase C-mediated cascade, FGFR2.)
R-HSA-5654227 (Phospholipase C-mediated cascade, FGFR3.)
R-HSA-5654228 (Phospholipase C-mediated cascade, FGFR4.)
R-HSA-5654687 (Downstream signaling of activated FGFR1.)
R-HSA-5654688 (SHC-mediated cascade:FGFR1.)
R-HSA-5654689 (PI-3K cascade:FGFR1.)
R-HSA-5654693 (FRS-mediated FGFR1 signaling.)
R-HSA-5654695 (PI-3K cascade:FGFR2.)
R-HSA-5654699 (SHC-mediated cascade:FGFR2.)
R-HSA-5654700 (FRS-mediated FGFR2 signaling.)
R-HSA-5654704 (SHC-mediated cascade:FGFR3.)
R-HSA-5654706 (FRS-mediated FGFR3 signaling.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654712 (FRS-mediated FGFR4 signaling.)
R-HSA-5654719 (SHC-mediated cascade:FGFR4.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5654726 (Negative regulation of FGFR1 signaling.)
R-HSA-5654727 (Negative regulation of FGFR2 signaling.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-5655253 (Signaling by FGFR2 in disease.)
R-HSA-5655302 (Signaling by FGFR1 in disease.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8851708 (Signaling by FGFR2 IIIa TM.)
R-HSA-8853338 (Signaling by FGFR3 point mutants in cancer.)
UniProt B2R5T0 D3DQF2 P05230 P07502 Q16588

Target Cross References - Domain

InterPro IPR002209 (Fibroblast_GF_fam.)
IPR008996 (Cytokine_IL1-like.)
IPR028142 (IL-1_fam/FGF_fam.)
IPR028210 (FGF1.)
Pfam PF00167 (FGF)

Target Cross References - Structure

PDBe 1AXM 1DJS 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1RG8 1RY7 1YTO 1Z2V More...
CREDO 1AXM 1DJS 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1RG8 1RY7 1YTO 1Z2V More...
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