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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL212
Target Type SINGLE PROTEIN
Preferred Name Integrin alpha-IIb
Synonyms CD_antigen=CD41 | GP2B | GPIIb | GPalpha IIb | ITGA2B | ITGAB | Integrin alpha-IIb heavy chain | Integrin alpha-IIb light chain, form 1 | Integrin alpha-IIb light chain, form 2 | Integrin alpha-IIb | Platelet membrane glycoprotein IIb
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-IIb SINGLE PROTEIN P08514

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111443 Integrin alpha-V/beta-3 and alpha-IIb/beta 3 SELECTIVITY GROUP
CHEMBL2093869 Integrin alpha-IIb/beta-3 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005961
Ensembl ENSG00000005961
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031092 (platelet alpha granule membrane)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0050840 (extracellular matrix binding)
GO:0070051 (fibrinogen binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0045652 (regulation of megakaryocyte differentiation)
GO:0070527 (platelet aggregation)
Wikipedia ITGA2B

Target Cross References - Protein

canSAR P08514
CGD Glanzmann thrombasthenia
Human Protein Atlas ENSG00000005961
IntAct P08514
Guide to Pharmacology 2440
Open Targets ENSG00000005961
PharmGKB PA29938
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-HSA-372708 (p130Cas linkage to MAPK signaling for integrins.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-8936459 (RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.)
TIMBAL Integrins
UniProt B2RCY8 O95366 P08514 Q14443 Q17R67

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
Pfam PF00357 (Integrin_alpha)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1TYE 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4Z7N More...
CREDO 1TYE 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4Z7N More...
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