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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2117
Preferred Name AMP-activated protein kinase, beta-2 subunit
Synonyms 5'-AMP-activated protein kinase subunit beta-2 | AMPK subunit beta-2 | PRKAB2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase subunit beta-2 SINGLE PROTEIN O43741

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038453 AMPK alpha1/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038457 AMPK alpha2/beta2/gamma3 PROTEIN COMPLEX
CHEMBL3038456 AMPK alpha2/beta2/gamma1 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131791
Ensembl ENSG00000131791
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0031588 (nucleotide-activated protein kinase complex)
GO Molecular Function GO:0004679 (AMP-activated protein kinase activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006853 (carnitine shuttle)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0016236 (macroautophagy)
GO:0016241 (regulation of macroautophagy)
GO:0042304 (regulation of fatty acid biosynthetic process)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia PRKAB2

Target Cross References - Protein

canSAR O43741
Human Protein Atlas ENSG00000131791
IntAct O43741
Guide to Pharmacology 1544
Open Targets ENSG00000131791
PharmGKB PA33747
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-163680 (AMPK inhibits chREBP transcriptional activation activity.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A8K9V5 B4DH06 O43741 Q5VXY0

Target Cross References - Domain

InterPro IPR006828 (ASC_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR032640 (AMPK1_CBM.)
IPR037256 (ASC_dom_sf.)
Pfam PF04739 (AMPKBI)
PF16561 (AMPK1_CBM)

Target Cross References - Structure

PDBe 2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW
CREDO 2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW