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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2116
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, alpha-2 subunit
Synonyms 5'-AMP-activated protein kinase catalytic subunit alpha-2 | ACACA kinase | AMPK | AMPK subunit alpha-2 | AMPK2 | Acetyl-CoA carboxylase kinase | HMGCR kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase ampk subfamily

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase catalytic subunit alpha-2 SINGLE PROTEIN P54646

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038457 AMPK alpha2/beta2/gamma3 PROTEIN COMPLEX
CHEMBL3038456 AMPK alpha2/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038455 AMPK alpha2/beta1/gamma1 PROTEIN COMPLEX
CHEMBL3038454 AMPK alpha1/alpha2 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162409
Ensembl ENSG00000162409
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031588 (nucleotide-activated protein kinase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035174 (histone serine kinase activity)
GO:0046872 (metal ion binding)
GO:0047322 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity)
GO:0050405 ([acetyl-CoA carboxylase] kinase activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006853 (carnitine shuttle)
GO:0006914 (autophagy)
GO:0006950 (response to stress)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008610 (lipid biosynthetic process)
GO:0010468 (regulation of gene expression)
GO:0010508 (positive regulation of autophagy)
GO:0014850 (response to muscle activity)
GO:0016055 (Wnt signaling pathway)
GO:0016126 (sterol biosynthetic process)
GO:0016236 (macroautophagy)
GO:0016239 (positive regulation of macroautophagy)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0016568 (chromatin modification)
GO:0031669 (cellular response to nutrient levels)
GO:0032007 (negative regulation of TOR signaling)
GO:0035404 (histone-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0035690 (cellular response to drug)
GO:0042149 (cellular response to glucose starvation)
GO:0042304 (regulation of fatty acid biosynthetic process)
GO:0042593 (glucose homeostasis)
GO:0042752 (regulation of circadian rhythm)
GO:0043066 (negative regulation of apoptotic process)
GO:0045821 (positive regulation of glycolytic process)
GO:0048511 (rhythmic process)
GO:0055089 (fatty acid homeostasis)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:2000505 (regulation of energy homeostasis)
Wikipedia PRKAA2

Target Cross References - Protein

canSAR P54646
Human Protein Atlas ENSG00000162409
IntAct P54646
Guide to Pharmacology 1542
Open Targets ENSG00000162409
PharmGKB PA33745
Pharos P54646 (Tchem)
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-163680 (AMPK inhibits chREBP transcriptional activation activity.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt P54646 Q9H1E8 Q9UD43

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR032270 (AMPK_C.)
Pfam PF00069 (Pkinase)
PF16579 (AdenylateSensor)

Target Cross References - Structure

PDBe 2H6D 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV
CREDO 2H6D 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV
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