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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2109
Target Type SINGLE PROTEIN
Preferred Name Dual specificity mitogen-activated protein kinase kinase 3
Synonyms Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPKK 3 | MEK 3 | MEK3 | MKK3 | PRKMK3 | SAPK kinase 2 | SAPKK-2 | SAPKK2 | SKK2 | Stress-activated protein kinase kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 3 SINGLE PROTEIN P46734

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000034152
Ensembl ENSG00000034152
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0035897 (proteolysis in other organism)
GO:0042035 (regulation of cytokine biosynthetic process)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0060048 (cardiac muscle contraction)
Wikipedia MAP2K3

Target Cross References - Protein

canSAR P46734
Human Protein Atlas ENSG00000034152
IntAct P46734
Guide to Pharmacology 2064
Open Targets ENSG00000034152
PharmGKB PA30588
Pharos P46734 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
UniProt B3KSK7 P46734 Q99441 Q9UE71 Q9UE72

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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