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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2108
Target Type SINGLE PROTEIN
Preferred Name Cyclin T1
Synonyms CCNT1 | CycT1 | Cyclin-T | Cyclin-T1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cyclin-T1 SINGLE PROTEIN O60563

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885549 Cyclin-T1/Cyclin-dependent-like kinase 5 PROTEIN COMPLEX
CHEMBL2111389 CDK9/cyclin T1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129315
Ensembl ENSG00000129315
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0008024 (cyclin/CDK positive transcription elongation factor complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
GO:0017069 (snRNA binding)
GO:0019901 (protein kinase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0070063 (RNA polymerase binding)
GO:0097322 (7SK snRNA binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0016032 (viral process)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
GO:0043923 (positive regulation by host of viral transcription)
GO:0045737 (positive regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050434 (positive regulation of viral transcription)
GO:0051301 (cell division)
GO:1900364 (negative regulation of mRNA polyadenylation)
GO:1901409 (positive regulation of phosphorylation of RNA polymerase II C-terminal domain)
Wikipedia Cyclin_T1

Target Cross References - Protein

canSAR O60563
Human Protein Atlas ENSG00000129315
IntAct O60563
Open Targets ENSG00000129315
PharmGKB PA26163
Reactome R-HSA-112382 (Formation of RNA Pol II elongation complex.)
R-HSA-167152 (Formation of HIV elongation complex in the absence of HIV Tat.)
R-HSA-167200 (Formation of HIV-1 elongation complex containing HIV-1 Tat.)
R-HSA-167238 (Pausing and recovery of Tat-mediated HIV elongation.)
R-HSA-167243 (Tat-mediated HIV elongation arrest and recovery.)
R-HSA-167246 (Tat-mediated elongation of the HIV-1 transcript.)
R-HSA-167287 (HIV elongation arrest and recovery.)
R-HSA-167290 (Pausing and recovery of HIV elongation.)
R-HSA-176034 (Interactions of Tat with host cellular proteins.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-674695 (RNA Polymerase II Pre-transcription Events.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
R-HSA-75955 (RNA Polymerase II Transcription Elongation.)
UniProt A9XU13 E7EX76 O60563 O60581

Target Cross References - Domain

InterPro IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR028863 (CCNT1.)
IPR036915 (Cyclin-like_sf.)
Pfam PF00134 (Cyclin_N)

Target Cross References - Structure

PDBe 2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z
CREDO 2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z
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