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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2107
Target Type SINGLE PROTEIN
Preferred Name C-X-C chemokine receptor type 4
Synonyms C-X-C chemokine receptor type 4 | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cxc chemokine receptor

Target Components

Component Description Relationship Accession
C-X-C chemokine receptor type 4 SINGLE PROTEIN P61073

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL18442 PLERIXAFOR C-X-C chemokine receptor type 4 partial agonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121966
Ensembl ENSG00000121966
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016021 (integral to membrane)
GO:0016023 (cytoplasmic membrane-bounded vesicle)
GO:0031252 (cell leading edge)
GO Molecular Function GO:0003779 (actin binding)
GO:0015026 (coreceptor activity)
GO:0016494 (C-X-C chemokine receptor activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032027 (myosin light chain binding)
GO:0043130 (ubiquitin binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0002407 (dendritic cell chemotaxis)
GO:0006915 (apoptosis)
GO:0006954 (inflammatory response)
GO:0007204 (elevation of cytosolic calcium ion concentration)
GO:0009615 (response to virus)
GO:0019059 (initiation of viral infection)
GO:0030260 (entry into host cell)
GO:0050920 (regulation of chemotaxis)
Wikipedia CXCR4

Target Cross References - Protein

canSAR P61073
CGD Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM syndrome)
Human Protein Atlas ENSG00000121966
IntAct P61073
IUPHAR 71 (CXCR4)
PharmGKB PA27058
Reactome REACT_14797 (Signaling by GPCR.)
REACT_6185 (HIV Infection.)
UniProt B2R5N0 O60835 P30991 P56438 P61073 Q53S69 Q9BXA0 Q9UKN2

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR001277 (Chemokine_CXCR4.)
IPR017452 (GPCR_Rhodpsn_supfam.)
IPR022726 (Chemokine_CXCR4_N.)
Pfam PF00001 (7tm_1)
PF12109 (CXCR4_N)

Target Cross References - Structure

PDBe 3ODU 3OE0 3OE6 3OE8 3OE9
CREDO 3ODU 3OE0 3OE6 3OE8 3OE9
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