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Target Report Card

Target Name and Classification

Target ID CHEMBL2104
Preferred Name P2X purinoceptor 4
Synonyms ATP receptor | P2RX4 | P2X purinoceptor 4 | P2X4 | Purinergic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > p2x receptor

Target Components

Component Description Relationship Accession
P2X purinoceptor 4 SINGLE PROTEIN Q99571

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135124
Ensembl ENSG00000135124
GO Cellular Component GO:0005639 (integral component of nuclear inner membrane)
GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001614 (purinergic nucleotide receptor activity)
GO:0004931 (extracellular ATP-gated cation channel activity)
GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0042803 (protein homodimerization activity)
GO:0045296 (cadherin binding)
GO Biological Process GO:0001894 (tissue homeostasis)
GO:0002028 (regulation of sodium ion transport)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0010614 (negative regulation of cardiac muscle hypertrophy)
GO:0019228 (neuronal action potential)
GO:0019233 (sensory perception of pain)
GO:0032308 (positive regulation of prostaglandin secretion)
GO:0033198 (response to ATP)
GO:0034220 (ion transmembrane transport)
GO:0034405 (response to fluid shear stress)
GO:0035590 (purinergic nucleotide receptor signaling pathway)
GO:0042118 (endothelial cell activation)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0051260 (protein homooligomerization)
GO:0051899 (membrane depolarization)
GO:0051928 (positive regulation of calcium ion transport)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0055119 (relaxation of cardiac muscle)
GO:0071318 (cellular response to ATP)
GO:0097190 (apoptotic signaling pathway)
GO:0098655 (cation transmembrane transport)
Wikipedia P2RX4

Target Cross References - Protein

canSAR Q99571
Human Protein Atlas ENSG00000135124
IntAct Q99571
Guide to Pharmacology 481
Open Targets ENSG00000135124
PharmGKB PA32864
Pharos Q99571 (Tchem)
Reactome R-HSA-139853 (Elevation of cytosolic Ca2+ levels.)
R-HSA-418346 (Platelet homeostasis.)
UniProt E7EPF7 F6RU17 O00450 O14722 Q5U089 Q5U090 Q8N4N1 Q99571 Q9UBG9

Target Cross References - Domain

InterPro IPR001429 (P2X_purnocptor.)
IPR003047 (P2X4_purnocptor.)
IPR027309 (P2X_extracellular_dom.)
Pfam PF00864 (P2X_receptor)