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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL210
Target Type SINGLE PROTEIN
Preferred Name Beta-2 adrenergic receptor
Synonyms ADRB2 | ADRB2R | B2AR | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P07550

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111388 Beta-2 adrenergic receptor and beta-3 adrenergic receptor SELECTIVITY GROUP
CHEMBL2096974 Adrenergic receptor beta; ADRB1 & ADRB2 SELECTIVITY GROUP
CHEMBL2094118 Adrenergic receptor beta PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL714 ALBUTEROL Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1201026 ALBUTEROL SULFATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1951071 ARFORMOTEROL TARTRATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1200405 BITOLTEROL MESYLATE Beta-2 adrenergic receptor agonist PubMed
CHEMBL1200418 DOBUTAMINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1201115 ESMOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL2303638 FORMOTEROL FUMARATE DIHYDRATE Beta-2 adrenergic receptor agonist DailyMed DailyMed
CHEMBL1789842 INDACATEROL MALEATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1200920 ISOETHARINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist ISBN
CHEMBL1201153 ISOETHARINE MESYLATE Beta-2 adrenergic receptor agonist ISBN
CHEMBL1201061 LEVALBUTEROL HYDROCHLORIDE Beta-2 adrenergic receptor agonist PubMed
CHEMBL2062258 LEVALBUTEROL TARTRATE Beta-2 adrenergic receptor agonist PubMed
CHEMBL1201177 LEVOBUNOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1200812 METAPROTERENOL SULFATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1200947 METIPRANOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL649 NADOLOL Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1201731 NEBIVOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL2105743 OLODATEROL HYDROCHLORIDE Beta-2 adrenergic receptor agonist FDA
CHEMBL1200745 OXPRENOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist ISBN PubMed
CHEMBL1200363 PENBUTOLOL SULFATE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL500 PINDOLOL Beta-2 adrenergic receptor partial agonist DailyMed
CHEMBL1200444 PIRBUTEROL ACETATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1201063 PROPAFENONE HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1671 PROPRANOLOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1200893 PROTOKYLOL HYDROCHLORIDE Beta-2 adrenergic receptor agonist PubMed
CHEMBL1201160 RITODRINE HYDROCHLORIDE Beta-2 adrenergic receptor agonist ISBN
CHEMBL1082607 SALMETEROL XINAFOATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL1700 SOTALOL HYDROCHLORIDE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1160544 TERBUTALINE SULFATE Beta-2 adrenergic receptor agonist DailyMed
CHEMBL499 TIMOLOL Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1200870 TIMOLOL MALEATE Beta-2 adrenergic receptor antagonist DailyMed
CHEMBL1084172 VILANTEROL TRIFENATATE Beta-2 adrenergic receptor agonist FDA
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169252
Ensembl ENSG00000169252
GO Cellular Component GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005887 (integral to plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004941 (beta2-adrenergic receptor activity)
GO:0015459 (potassium channel regulator activity)
GO:0042803 (protein homodimerization activity)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0006898 (receptor-mediated endocytosis)
GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
GO:0008333 (endosome to lysosome transport)
GO:0043410 (positive regulation of MAPKKK cascade)
Wikipedia Beta-2_adrenergic_receptor

Target Cross References - Protein

CGD Beta-2-adrenoreceptor agonist, reduced response to
Human Protein Atlas ENSG00000169252
IntAct P07550
Guide to Pharmacology 29 (Beta;2-adrenoceptor)
PharmGKB PA39
Reactome REACT_14797 (Signaling by GPCR.)
UniProt B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 P07550 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000332 (Adrgc_rcpt_B2.)
IPR002233 (Adrnrgc_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS
CREDO 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS
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