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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2099
Target Type SINGLE PROTEIN
Preferred Name Prostate specific antigen
Synonyms APS | Gamma-seminoprotein | KLK3 | Kallikrein-3 | P-30 antigen | PSA | Prostate-specific antigen | Semenogelase | Seminin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Prostate-specific antigen SINGLE PROTEIN P07288

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142515
Ensembl ENSG00000142515
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
GO Biological Process GO:0002778 (antibacterial peptide production)
GO:0006508 (proteolysis)
GO:0016525 (negative regulation of angiogenesis)
GO:0044267 (cellular protein metabolic process)
Wikipedia Prostate-specific_antigen

Target Cross References - Protein

canSAR P07288
Human Protein Atlas ENSG00000142515
IntAct P07288
Guide to Pharmacology 2373
Open Targets ENSG00000142515
PharmGKB PA164741810
Reactome R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-5625886 (Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.)
UniProt C9JXH3 G3V0H4 G3XAE3 P07288 Q15096 Q16272 Q86TG8 Q8IXI4

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 2ZCH 2ZCK 2ZCL 3QUM
CREDO 2ZCH 2ZCK 2ZCL 3QUM
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