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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2086
Preferred Name Voltage-gated potassium channel subunit Kv1.2
Synonyms KCNA2 | NGK1 | Potassium voltage-gated channel subfamily A member 2 | Voltage-gated K(+) channel HuKIV | Voltage-gated potassium channel HBK5 | Voltage-gated potassium channel subunit Kv1.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily A member 2 SINGLE PROTEIN P16389

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177301
Ensembl ENSG00000177301
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031258 (lamellipodium membrane)
GO:0032809 (neuronal cell body membrane)
GO:0042734 (presynaptic membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0044224 (juxtaparanode region of axon)
GO:0045202 (synapse)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0014059 (regulation of dopamine secretion)
GO:0019228 (neuronal action potential)
GO:0019233 (sensory perception of pain)
GO:0021633 (optic nerve structural organization)
GO:0034765 (regulation of ion transmembrane transport)
GO:0045188 (regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0051260 (protein homooligomerization)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
Wikipedia KCNA2

Target Cross References - Protein

canSAR P16389
Human Protein Atlas ENSG00000177301
IntAct P16389
Guide to Pharmacology 539
Open Targets ENSG00000177301
PharmGKB PA206
Pharos P16389 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
UniProt A0A024R0D3 A8K1Z6 P16389 Q86XG6

Target Cross References - Domain

InterPro IPR000210 (BTB/POZ_dom.)
IPR003131 (T1-type_BTB.)
IPR003968 (K_chnl_volt-dep_Kv.)
IPR003972 (K_chnl_volt-dep_Kv1.)
IPR004049 (K_chnl_volt-dep_Kv1.2.)
IPR005821 (Ion_trans_dom.)
IPR011333 (SKP1/BTB/POZ.)
IPR027359 (Channel_four-helix_dom.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF02214 (BTB_2)