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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2085
Target Type SINGLE PROTEIN
Preferred Name Macrophage migration inhibitory factor
Synonyms GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF | MMIF | Macrophage migration inhibitory factor | Phenylpyruvate tautomerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Macrophage migration inhibitory factor SINGLE PROTEIN P14174

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111430 MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000240972 ENSG00000276701
Ensembl ENSG00000240972 ENSG00000276701
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0031982 (vesicle)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004167 (dopachrome isomerase activity)
GO:0005102 (receptor binding)
GO:0005125 (cytokine activity)
GO:0005126 (cytokine receptor binding)
GO:0005515 (protein binding)
GO:0016853 (isomerase activity)
GO:0042056 (chemoattractant activity)
GO:0050178 (phenylpyruvate tautomerase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002376 (immune system process)
GO:0002906 (negative regulation of mature B cell apoptotic process)
GO:0006954 (inflammatory response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007569 (cell aging)
GO:0008283 (cell proliferation)
GO:0010629 (negative regulation of gene expression)
GO:0010739 (positive regulation of protein kinase A signaling)
GO:0019752 (carboxylic acid metabolic process)
GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
GO:0030890 (positive regulation of B cell proliferation)
GO:0031666 (positive regulation of lipopolysaccharide-mediated signaling pathway)
GO:0032269 (negative regulation of cellular protein metabolic process)
GO:0033033 (negative regulation of myeloid cell apoptotic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042327 (positive regulation of phosphorylation)
GO:0043030 (regulation of macrophage activation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0045087 (innate immune response)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
GO:0050918 (positive chemotaxis)
GO:0061078 (positive regulation of prostaglandin secretion involved in immune response)
GO:0061081 (positive regulation of myeloid leukocyte cytokine production involved in immune response)
GO:0070207 (protein homotrimerization)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0090238 (positive regulation of arachidonic acid secretion)
GO:0090344 (negative regulation of cell aging)
GO:1902166 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:2000343 (positive regulation of chemokine (C-X-C motif) ligand 2 production)
Wikipedia Macrophage_migration_inhibitory_factor

Target Cross References - Protein

canSAR P14174
Human Protein Atlas ENSG00000240972 ENSG00000276701
IntAct P14174
Open Targets ENSG00000240972 ENSG00000276701
PharmGKB PA30819
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-6798695 (Neutrophil degranulation.)
TIMBAL CD74
UniProt A5Z1R8 B2R4S3 P14174 Q2V4Y5 Q6FHV0

Target Cross References - Domain

InterPro IPR001398 (Macrophage_inhib_fac.)
IPR014347 (Tautomerase/MIF_sf.)
IPR019829 (Macrophage_inhib_fac_CS.)
Pfam PF01187 (MIF)

Target Cross References - Structure

PDBe 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S More...
CREDO 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S More...
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