ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2085
Target Type SINGLE PROTEIN
Preferred Name Macrophage migration inhibitory factor
Synonyms GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF | MMIF | Macrophage migration inhibitory factor | Phenylpyruvate tautomerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Macrophage migration inhibitory factor SINGLE PROTEIN P14174

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111430 MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000240972
Ensembl ENSG00000240972
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO Molecular Function GO:0004167 (dopachrome isomerase activity)
GO:0005125 (cytokine activity)
GO:0005126 (cytokine receptor binding)
GO:0042056 (chemoattractant activity)
GO:0043498 (cell surface binding)
GO:0050178 (phenylpyruvate tautomerase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006954 (inflammatory response)
GO:0007166 (cell surface receptor linked signaling pathway)
GO:0008283 (cell proliferation)
GO:0010629 (negative regulation of gene expression)
GO:0010739 (positive regulation of protein kinase A signaling cascade)
GO:0030890 (positive regulation of B cell proliferation)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0043030 (regulation of macrophage activation)
GO:0043066 (negative regulation of apoptosis)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0045087 (innate immune response)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0070207 (protein homotrimerization)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071157 (negative regulation of cell cycle arrest)
Wikipedia Macrophage_migration_inhibitory_factor

Target Cross References - Protein

canSAR P14174
Human Protein Atlas ENSG00000240972
IntAct P14174
PharmGKB PA30819
TIMBAL CD74
UniProt A5Z1R8 B2R4S3 P14174 Q2V4Y5 Q6FHV0

Target Cross References - Domain

InterPro IPR001398 (Macrophage_inhib_fac.)
IPR014347 (Tautomerase.)
IPR019829 (Macrophage_inhib_fac_CS.)
Pfam PF01187 (MIF)

Target Cross References - Structure

PDBe 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S More...
CREDO 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S More...
spacer
spacer