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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2081
Target Type SINGLE PROTEIN
Preferred Name Glutathione S-transferase Mu 1
Synonyms GST HB subunit 4 | GST class-mu 1 | GST1 | GSTM1 | GSTM1-1 | GSTM1a-1a | GSTM1b-1b | GTH4 | Glutathione S-transferase Mu 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase Mu 1 SINGLE PROTEIN P09488

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134184
Ensembl ENSG00000134184
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0045171 (intercellular bridge)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0043295 (glutathione binding)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0008152 (metabolic process)
GO:0018916 (nitrobenzene metabolic process)
GO:0042178 (xenobiotic catabolic process)
GO:0070458 (cellular detoxification of nitrogen compound)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia Glutathione_S-transferase_Mu_1

Target Cross References - Protein

canSAR P09488
Human Protein Atlas ENSG00000134184
IntAct P09488
Open Targets ENSG00000134184
PharmGKB PA182
Reactome R-HSA-156590 (Glutathione conjugation.)
UniProt P09488 Q5GHG0 Q6FH88 Q8TC98 Q9UC96

Target Cross References - Domain

InterPro IPR003081 (GST_mu.)
IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR036249 (Thioredoxin-like_sf.)
IPR036282 (Glutathione-S-Trfase_C_sf.)
Pfam PF02798 (GST_N)
PF14497 (GST_C_3)

Target Cross References - Structure

PDBe 1GTU 1XW6 1XWK 1YJ6 2F3M
CREDO 1GTU 1XW6 1XWK 1YJ6 2F3M
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