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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL208
Target Type SINGLE PROTEIN
Preferred Name Progesterone receptor
Synonyms NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | Progesterone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 3

Target Components

Component Description Relationship Accession
Progesterone receptor SINGLE PROTEIN P06401

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL103 PROGESTERONE Progesterone receptor agonist 4 PubMed
CHEMBL717 MEDROXYPROGESTERONE ACETATE Progesterone receptor agonist 4 DailyMed
CHEMBL1162 NORETHINDRONE Progesterone receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1387 NORETHYNODREL Progesterone receptor agonist 4 PubMed PubMed PubMed
CHEMBL1389 LEVONORGESTREL Progesterone receptor agonist 4 PubMed
CHEMBL1479 DANAZOL Progesterone receptor agonist 4 DailyMed FDA ISBN PubMed
CHEMBL1509 DROSPIRENONE Progesterone receptor agonist 4 DailyMed PubMed
CHEMBL1531 ETONOGESTREL Progesterone receptor agonist 4 ISBN
CHEMBL1533 DESOGESTREL Progesterone receptor agonist 4 ISBN
CHEMBL260538 ULIPRISTAL ACETATE Progesterone receptor modulator 4 FDA
CHEMBL1200624 ETHYNODIOL DIACETATE Progesterone receptor agonist 4 KEGG PubMed PubMed PubMed
CHEMBL1200807 NORELGESTROMIN Progesterone receptor agonist 4 DailyMed
CHEMBL1200848 HYDROXYPROGESTERONE CAPROATE Progesterone receptor agonist 4 PubMed PubMed
CHEMBL1200853 DYDROGESTERONE Progesterone receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200934 NORGESTIMATE Progesterone receptor agonist 4 DailyMed
CHEMBL1201139 MEGESTROL ACETATE Progesterone receptor agonist 4 PubMed PubMed
CHEMBL1201146 NORETHINDRONE ACETATE Progesterone receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1276308 MIFEPRISTONE Progesterone receptor antagonist 4 DailyMed
CHEMBL1908373 ONAPRISTONE Progesterone receptor antagonist 4 Other PubMed
CHEMBL2103846 ULIPRISTAL Progesterone receptor modulator 4 PubMed
CHEMBL2107797 NORGESTREL Progesterone receptor agonist 4 Expert
CHEMBL267431 ASOPRISNIL Progesterone receptor modulator 3 PubMed PubMed
CHEMBL2105694 TELAPRISTONE ACETATE Progesterone receptor modulator 3 Other PubMed
CHEMBL146032 LONAPRISAN Progesterone receptor antagonist 2 PubMed
CHEMBL3545239 PF-05019702 Progesterone receptor antagonist 1 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000082175
Ensembl ENSG00000082175
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0005102 (receptor binding)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019899 (enzyme binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0010629 (negative regulation of gene expression)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia Progesterone_receptor

Target Cross References - Protein

canSAR P06401
Human Protein Atlas ENSG00000082175
IntAct P06401
Guide to Pharmacology 627
Open Targets ENSG00000082175
PharmGKB PA266
Pharos P06401 (Tclin)
Reactome R-HSA-1251985 (Nuclear signaling by ERBB4.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A7LQ08 A7X8B0 B4E3T0 P06401 Q8TDS3 Q9UPF7

Target Cross References - Domain

InterPro IPR000128 (Progest_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02161 (Prog_receptor)

Target Cross References - Structure

PDBe 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
CREDO 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
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