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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL208
Target Type SINGLE PROTEIN
Preferred Name Progesterone receptor
Synonyms NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | Progesterone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 3

Target Components

Component Description Relationship Accession
Progesterone receptor SINGLE PROTEIN P06401

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1479 DANAZOL Progesterone receptor agonist DailyMed ISBN PubMed
CHEMBL1533 DESOGESTREL Progesterone receptor agonist ISBN
CHEMBL1509 DROSPIRENONE Progesterone receptor agonist DailyMed PubMed
CHEMBL1200853 DYDROGESTERONE Progesterone receptor agonist PubMed PubMed PubMed
CHEMBL1200624 ETHYNODIOL DIACETATE Progesterone receptor agonist KEGG PubMed PubMed PubMed
CHEMBL1531 ETONOGESTREL Progesterone receptor agonist ISBN
CHEMBL1473 FLUTICASONE PROPIONATE Progesterone receptor agonist DailyMed
CHEMBL1200848 HYDROXYPROGESTERONE CAPROATE Progesterone receptor agonist PubMed PubMed
CHEMBL1389 LEVONORGESTREL Progesterone receptor agonist PubMed
CHEMBL717 MEDROXYPROGESTERONE ACETATE Progesterone receptor agonist DailyMed
CHEMBL1201139 MEGESTROL ACETATE Progesterone receptor agonist PubMed PubMed
CHEMBL1276308 MIFEPRISTONE Progesterone receptor antagonist DailyMed
CHEMBL1200807 NORELGESTROMIN Progesterone receptor agonist DailyMed
CHEMBL1162 NORETHINDRONE Progesterone receptor agonist PubMed PubMed PubMed PubMed
CHEMBL1201146 NORETHINDRONE ACETATE Progesterone receptor agonist PubMed PubMed PubMed PubMed
CHEMBL1387 NORETHYNODREL Progesterone receptor agonist PubMed PubMed PubMed
CHEMBL1200934 NORGESTIMATE Progesterone receptor agonist DailyMed
CHEMBL2107797 NORGESTREL Progesterone receptor agonist Expert
CHEMBL103 PROGESTERONE Progesterone receptor agonist PubMed
CHEMBL260538 ULIPRISTAL ACETATE Progesterone receptor modulator FDA
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000082175
Ensembl ENSG00000082175
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0005102 (receptor binding)
GO:0005496 (steroid binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO Biological Process GO:0007267 (cell-cell signaling)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
Wikipedia Progesterone_receptor

Target Cross References - Protein

canSAR P06401
Human Protein Atlas ENSG00000082175
IntAct P06401
Guide to Pharmacology 627 (Progesterone receptor)
PharmGKB PA266
Reactome REACT_71 (Gene Expression.)
UniProt A7X8B0 P06401 Q9UPF7

Target Cross References - Domain

InterPro IPR000128 (Progest_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02161 (Prog_receptor)

Target Cross References - Structure

PDBe 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8N 3G8O 3HQ5 3KBA
CREDO 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8N 3G8O 3HQ5 3KBA
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