ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2077
Preferred Name Alcohol sulfotransferase
Synonyms Bile salt sulfotransferase | DHEA-ST | Dehydroepiandrosterone sulfotransferase | HST | HST | Hydroxysteroid Sulfotransferase | ST2 | ST2A1 | ST2A3 | STD | SULT2A1 | Sulfotransferase 2A1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Bile salt sulfotransferase SINGLE PROTEIN Q06520

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105398
Ensembl ENSG00000105398
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004062 (aryl sulfotransferase activity)
GO:0004304 (estrone sulfotransferase activity)
GO:0005515 (protein binding)
GO:0008146 (sulfotransferase activity)
GO:0016740 (transferase activity)
GO:0047704 (bile-salt sulfotransferase activity)
GO:0050294 (steroid sulfotransferase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0007586 (digestion)
GO:0008202 (steroid metabolic process)
GO:0016042 (lipid catabolic process)
GO:0030573 (bile acid catabolic process)
GO:0050427 (3'-phosphoadenosine 5'-phosphosulfate metabolic process)
GO:0051923 (sulfation)
Wikipedia Bile_salt_sulfotransferase

Target Cross References - Protein

canSAR Q06520
Human Protein Atlas ENSG00000105398
IntAct Q06520
Open Targets ENSG00000105398
PharmGKB PA346
Reactome R-HSA-156584 (Cytosolic sulfonation of small molecules.)
R-HSA-1989781 (PPARA activates gene expression.)
UniProt Q06520

Target Cross References - Domain

InterPro IPR000863 (Sulfotransferase_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00685 (Sulfotransfer_1)

Target Cross References - Structure

PDBe 1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
CREDO 1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB