ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2074
Target Type SINGLE PROTEIN
Preferred Name Maltase-glucoamylase
Synonyms Alpha-glucosidase | Glucan 1,4-alpha-glucosidase | Glucoamylase | MGA | MGAM | MGAML | Maltase | Maltase-glucoamylase, intestinal
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Maltase-glucoamylase, intestinal SINGLE PROTEIN O43451

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1561 MIGLITOL Maltase-glucoamylase inhibitor 4 DailyMed PubMed
CHEMBL1566 ACARBOSE Maltase-glucoamylase inhibitor 4 DailyMed InterPro

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179087
Ensembl ENSG00000179087
GO Cellular Component GO:0016021 (integral to membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0004339 (glucan 1,4-alpha-glucosidase activity)
GO:0030246 (carbohydrate binding)
GO:0032450 (maltose alpha-glucosidase activity)
GO Biological Process GO:0005983 (starch catabolic process)
GO:0044245 (polysaccharide digestion)
Wikipedia Maltase-glucoamylase

Target Cross References - Protein

canSAR O43451
Human Protein Atlas ENSG00000179087
IntAct O43451
Guide to Pharmacology 2627 (maltase-glucoamylase (alpha-glucosidase))
PharmGKB PA30778
Reactome REACT_474 (Metabolism of carbohydrates.)
UniProt O43451 Q0VAX6 Q75ME7 Q86UM5

Target Cross References - Domain

InterPro IPR000322 (Glyco_hydro_31.)
IPR000519 (P_trefoil.)
IPR011013 (Glyco_hydro-type_carb-bd.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR017957 (P_trefoil_CS.)
Pfam PF00088 (Trefoil)
PF01055 (Glyco_hydro_31)

Target Cross References - Structure

PDBe 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z
CREDO 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z
spacer
spacer