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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2073
Preferred Name Tyrosine-protein kinase YES
Synonyms Proto-oncogene c-Yes | Tyrosine-protein kinase Yes | YES | YES1 | p61-Yes
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Yes SINGLE PROTEIN P07947

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase YES inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176105
Ensembl ENSG00000176105
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0031295 (T cell costimulation)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0043114 (regulation of vascular permeability)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
GO:0071300 (cellular response to retinoic acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
Wikipedia YES1

Target Cross References - Protein

canSAR P07947
Human Protein Atlas ENSG00000176105
IntAct P07947
Guide to Pharmacology 2284
Open Targets ENSG00000176105
PharmGKB PA37432
Pharos P07947 (Tclin)
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-2029481 (FCGR activation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-912631 (Regulation of signaling by CBL.)
UniProt A6NLB3 D3DUH1 P07947

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure