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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2073
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase YES
Synonyms Proto-oncogene c-Yes | Tyrosine-protein kinase Yes | YES | YES1 | p61-Yes
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Yes SINGLE PROTEIN P07947

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase YES inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176105
Ensembl ENSG00000176105
GO Cellular Component GO:0005815 (microtubule organizing center)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0070062 (extracellular exosome)
GO:0005884 (actin filament)
GO:0005737 (cytoplasm)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0005102 (receptor binding)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0019899 (enzyme binding)
GO:0044325 (ion channel binding)
GO:0005524 (ATP binding)
GO:0004713 (protein tyrosine kinase activity)
GO Biological Process GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007596 (blood coagulation)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0050900 (leukocyte migration)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0043114 (regulation of vascular permeability)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0007411 (axon guidance)
GO:0045087 (innate immune response)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0071300 (cellular response to retinoic acid)
GO:0030154 (cell differentiation)
GO:0006464 (cellular protein modification process)
GO:0015758 (glucose transport)
GO:0031295 (T cell costimulation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia YES1

Target Cross References - Protein

canSAR P07947
Human Protein Atlas ENSG00000176105
IntAct P07947
Guide to Pharmacology 2284 (YES proto-oncogene 1, Src family tyrosine kinase)
PharmGKB PA37432
UniProt A6NLB3 D3DUH1 P07947

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR028459 (FGR.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF00017 (SH2)

Target Cross References - Structure

PDBe 2HDA
CREDO 2HDA
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