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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2073
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase YES
Synonyms Proto-oncogene c-Yes | Tyrosine-protein kinase Yes | YES | YES1 | p61-Yes
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Yes SINGLE PROTEIN P07947

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase YES inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176105
Ensembl ENSG00000176105
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0031295 (T cell costimulation)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0043114 (regulation of vascular permeability)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
GO:0071300 (cellular response to retinoic acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
Wikipedia YES1

Target Cross References - Protein

canSAR P07947
Human Protein Atlas ENSG00000176105
IntAct P07947
Guide to Pharmacology 2284
Open Targets ENSG00000176105
PharmGKB PA37432
Pharos P07947 (Tclin)
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-2029481 (FCGR activation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-912631 (Regulation of signaling by CBL.)
UniProt A6NLB3 D3DUH1 P07947

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2HDA
CREDO 2HDA
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