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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2072
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type IV alpha subunit
Synonyms SCN4A | SkM1 | Sodium channel protein skeletal muscle subunit alpha | Sodium channel protein type 4 subunit alpha | Sodium channel protein type IV subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 4 subunit alpha SINGLE PROTEIN P35499

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1098 BUPIVACAINE Sodium channel protein type IV alpha subunit blocker 4 PubMed
CHEMBL1404 RANOLAZINE Sodium channel protein type IV alpha subunit blocker 4 PubMed
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE Sodium channel protein type IV alpha subunit blocker 4 PubMed
CHEMBL1200749 LEVOBUPIVACAINE HYDROCHLORIDE Sodium channel protein type IV alpha subunit blocker 4 PubMed
CHEMBL2107771 RALFINAMIDE Sodium channel protein type IV alpha subunit blocker 3
CHEMBL3545170 TV-45070 Sodium channel protein type IV alpha subunit blocker 2
CHEMBL3545207 NW-3509 Sodium channel protein type IV alpha subunit blocker 1
CHEMBL3545209 NKTR-171 Sodium channel protein type IV alpha subunit blocker 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007314
Ensembl ENSG00000007314
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO Molecular Function GO:0005248 (voltage-gated sodium channel activity)
GO Biological Process GO:0006936 (muscle contraction)
Wikipedia Nav1.4

Target Cross References - Protein

canSAR P35499
CGD Paramyotonia congenita; Hyperkalemic periodic paralysis, type 2; Hypokalemic periodic paralysis, type 2; Normokalemic potassium-sensitive periodic paralysis; Malignant hyperthermia, susceptibility to; Myasthenic syndrome, congenital, acetazalomide-responsive (AR); Myotonia, potassium-aggravated
Human Protein Atlas ENSG00000007314
Guide to Pharmacology 581 (Nav1.4)
PharmGKB PA35006
Reactome REACT_18266 (Axon guidance.)
UniProt P35499 Q15478 Q16447 Q7Z6B1

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans.)
IPR008052 (Na_channel_a4su.)
IPR010526 (Na_trans_assoc.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
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