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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2068
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 2
Synonyms ECK | EPHA2 | Ephrin type-A receptor 2 | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 2 SINGLE PROTEIN P29317

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1421 DASATINIB Ephrin type-A receptor 2 inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142627
Ensembl ENSG00000142627
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0005925 (focal adhesion)
GO:0031258 (lamellipodium membrane)
GO:0032587 (ruffle membrane)
GO Molecular Function GO:0005003 (ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptosis)
GO:0010591 (regulation of lamellipodium assembly)
GO:0032863 (activation of Rac GTPase activity)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0043491 (protein kinase B signaling cascade)
GO:0043535 (regulation of blood vessel endothelial cell migration)
GO:0048013 (ephrin receptor signaling pathway)
GO:0051898 (negative regulation of protein kinase B signaling cascade)
GO:0060326 (cell chemotaxis)
GO:0070848 (response to growth factor stimulus)
GO:0090004 (positive regulation of establishment of protein localization in plasma membrane)
Wikipedia EPH_receptor_A2

Target Cross References - Protein

canSAR P29317
CGD Cataract, age-related cortical, 2; Cataract, posterior polar, 1
Human Protein Atlas ENSG00000142627
IntAct P29317
Guide to Pharmacology 1822 (EPH receptor A2)
PharmGKB PA27818
UniProt P29317 Q8N3Z2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001090 (Ephrin_rcpt_lig-bd.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001426 (Tyr_prot_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN_III.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR008957 (Fibronectin_III_dom.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt.)
IPR010993 (Sterile_alpha_motif_homology.)
IPR011009 (Kinase-like_dom.)
IPR013761 (SAM_type.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_prot_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR021129 (SAM_type1.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1MQB 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0
CREDO 1MQB 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0
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