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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2062
Preferred Name Ryanodine receptor 3
Synonyms Brain ryanodine receptor-calcium release channel | Brain-type ryanodine receptor | HBRR | RYR-3 | RYR3 | RyR3 | Ryanodine receptor 3 | Type 3 ryanodine receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ryanodine receptor

Target Components

Component Description Relationship Accession
Ryanodine receptor 3 SINGLE PROTEIN Q15413

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL928 DANTROLENE SODIUM Ryanodine receptor 3 antagonist 4 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198838
Ensembl ENSG00000198838
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0031090 (organelle membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005219 (ryanodine-sensitive calcium-release channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005516 (calmodulin binding)
GO:0015278 (calcium-release channel activity)
GO:0048763 (calcium-induced calcium release activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0034220 (ion transmembrane transport)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051289 (protein homotetramerization)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0071277 (cellular response to calcium ion)
GO:0071286 (cellular response to magnesium ion)
GO:0071313 (cellular response to caffeine)
GO:0071318 (cellular response to ATP)
GO:1903779 (regulation of cardiac conduction)
Wikipedia RYR3

Target Cross References - Protein

Human Protein Atlas ENSG00000198838
IntAct Q15413
Guide to Pharmacology 749
Open Targets ENSG00000198838
PharmGKB PA34897
Pharos Q15413 (Tclin)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
R-HSA-5578775 (Ion homeostasis.)
UniProt O15175 Q15412 Q15413

Target Cross References - Domain

InterPro IPR000699 (RIH_dom.)
IPR001870 (B30.2/SPRY.)
IPR002048 (EF_hand_dom.)
IPR003032 (Ryanodine_rcpt.)
IPR003877 (SPRY_dom.)
IPR005821 (Ion_trans_dom.)
IPR009460 (Ryanrecept_TM4-6.)
IPR011992 (EF-hand-dom_pair.)
IPR013320 (ConA-like_dom_sf.)
IPR013333 (Ryan_recept.)
IPR013662 (RIH_assoc-dom.)
IPR014821 (Ins145_P3_rcpt.)
IPR015925 (Ryanodine_recept-rel.)
IPR016024 (ARM-type_fold.)
IPR016093 (MIR_motif.)
IPR035761 (SPRY1_RyR.)
IPR035762 (SPRY3_RyR.)
IPR035764 (SPRY2_RyR.)
IPR035910 (RyR/IP3R_RIH_dom_sf.)
IPR036300 (MIR_dom_sf.)
Pfam PF00520 (Ion_trans)
PF00622 (SPRY)
PF02026 (RyR)
PF02815 (MIR)
PF06459 (RR_TM4-6)
PF08454 (RIH_assoc)
PF08709 (Ins145_P3_rec)

Target Cross References - Structure