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Target Report Card

Target Name and Classification

Target ID CHEMBL2061
Preferred Name Retinoid X receptor alpha
Synonyms NR2B1 | Nuclear receptor subfamily 2 group B member 1 | RXRA | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-alpha SINGLE PROTEIN P19793

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363070 Retinoid X receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL3430883 Retinoic acid receptor alpha/Retinoid X receptor alpha PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1716091 SDX-101 Retinoid X receptor alpha modulator 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186350
Ensembl ENSG00000186350
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0030424 (axon)
GO:0043235 (receptor complex)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004886 (9-cis retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0032403 (protein complex binding)
GO:0042809 (vitamin D receptor binding)
GO:0042974 (retinoic acid receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0070644 (vitamin D response element binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001701 (in utero embryonic development)
GO:0001889 (liver development)
GO:0001890 (placenta development)
GO:0001893 (maternal placenta development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006766 (vitamin metabolic process)
GO:0006954 (inflammatory response)
GO:0007494 (midgut development)
GO:0007507 (heart development)
GO:0007565 (female pregnancy)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008203 (cholesterol metabolic process)
GO:0008285 (negative regulation of cell proliferation)
GO:0010269 (response to selenium ion)
GO:0014070 (response to organic cyclic compound)
GO:0015721 (bile acid and bile salt transport)
GO:0016032 (viral process)
GO:0019048 (modulation by virus of host morphology or physiology)
GO:0031103 (axon regeneration)
GO:0031641 (regulation of myelination)
GO:0032526 (response to retinoic acid)
GO:0032869 (cellular response to insulin stimulus)
GO:0033189 (response to vitamin A)
GO:0033280 (response to vitamin D)
GO:0035357 (peroxisome proliferator activated receptor signaling pathway)
GO:0043010 (camera-type eye development)
GO:0043065 (positive regulation of apoptotic process)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0044255 (cellular lipid metabolic process)
GO:0045471 (response to ethanol)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045994 (positive regulation of translational initiation by iron)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0051289 (protein homotetramerization)
GO:0051384 (response to glucocorticoid)
GO:0055010 (ventricular cardiac muscle tissue morphogenesis)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060038 (cardiac muscle cell proliferation)
GO:0060528 (secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)
GO:0060687 (regulation of branching involved in prostate gland morphogenesis)
GO:1901522 (positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)
Wikipedia Retinoid_X_receptor_alpha

Target Cross References - Protein

canSAR P19793
Human Protein Atlas ENSG00000186350
IntAct P19793
Guide to Pharmacology 610
Open Targets ENSG00000186350
PharmGKB PA34890
Pharos P19793 (Tclin)
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-192105 (Synthesis of bile acids and bile salts.)
R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
R-HSA-400253 (Circadian Clock.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
UniProt B3KY83 P19793 Q2NL52 Q2V504

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR021780 (Nuc_recep-AF1.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF11825 (Nuc_recep-AF1)

Target Cross References - Structure

PDBe 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...
CREDO 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...