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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2061
Target Type SINGLE PROTEIN
Preferred Name Retinoid X receptor alpha
Synonyms NR2B1 | Nuclear receptor subfamily 2 group B member 1 | RXRA | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-alpha SINGLE PROTEIN P19793

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111394 RXR alpha/PPAR gamma PROTEIN COMPLEX
CHEMBL3430878 Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta PROTEIN COMPLEX
CHEMBL3885613 Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha PROTEIN COMPLEX
CHEMBL2363070 Retinoid X receptor PROTEIN FAMILY
CHEMBL3430879 Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha PROTEIN COMPLEX
CHEMBL3885631 Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta PROTEIN COMPLEX
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL3885633 Retinoic acid receptor RXR-alpha/gamma PROTEIN COMPLEX
CHEMBL3430883 Retinoic acid receptor alpha/Retinoid X receptor alpha PROTEIN COMPLEX
CHEMBL3885632 Retinoic acid receptor RXR-alpha/Vitamin D3 receptor PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL53418 DANTHRON Retinoid X receptor alpha antagonist 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL1716091 SDX-101 Retinoid X receptor alpha modulator 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186350
Ensembl ENSG00000186350
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0032991 (macromolecular complex)
GO:0043235 (receptor complex)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001972 (retinoic acid binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004886 (9-cis retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016922 (ligand-dependent nuclear receptor binding)
GO:0019899 (enzyme binding)
GO:0031490 (chromatin DNA binding)
GO:0042277 (peptide binding)
GO:0042809 (vitamin D receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050692 (DBD domain binding)
GO:0050693 (LBD domain binding)
GO:0070644 (vitamin D response element binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001701 (in utero embryonic development)
GO:0001890 (placenta development)
GO:0001893 (maternal placenta development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006766 (vitamin metabolic process)
GO:0007507 (heart development)
GO:0007566 (embryo implantation)
GO:0008203 (cholesterol metabolic process)
GO:0015721 (bile acid and bile salt transport)
GO:0016032 (viral process)
GO:0019048 (modulation by virus of host morphology or physiology)
GO:0019216 (regulation of lipid metabolic process)
GO:0032526 (response to retinoic acid)
GO:0035357 (peroxisome proliferator activated receptor signaling pathway)
GO:0043010 (camera-type eye development)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045994 (positive regulation of translational initiation by iron)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0051289 (protein homotetramerization)
GO:0055010 (ventricular cardiac muscle tissue morphogenesis)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060038 (cardiac muscle cell proliferation)
GO:0060528 (secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)
GO:0060687 (regulation of branching involved in prostate gland morphogenesis)
GO:1901522 (positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)
Wikipedia Retinoid_X_receptor_alpha

Target Cross References - Protein

canSAR P19793
Human Protein Atlas ENSG00000186350
IntAct P19793
Guide to Pharmacology 610
Open Targets ENSG00000186350
PharmGKB PA34890
Pharos P19793 (Tclin)
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-192105 (Synthesis of bile acids and bile salts.)
R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
R-HSA-400253 (Circadian Clock.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-8951671 (RUNX3 regulates YAP1-mediated transcription.)
UniProt B3KY83 P19793 Q2NL52 Q2V504

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR021780 (Nuc_recep-AF1.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF11825 (Nuc_recep-AF1)

Target Cross References - Structure

PDBe 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...
CREDO 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...
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