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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2061
Target Type SINGLE PROTEIN
Preferred Name Retinoid X receptor alpha
Synonyms NR2B1 | Nuclear receptor subfamily 2 group B member 1 | RXRA | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 1

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-alpha SINGLE PROTEIN P19793

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111394 RXR alpha/PPAR gamma PROTEIN COMPLEX
CHEMBL2363070 Retinoid X receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186350
Ensembl ENSG00000186350
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003706 (ligand-regulated transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004886 (retinoid-X receptor activity)
GO:0005496 (steroid binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0042809 (vitamin D receptor binding)
GO:0044323 (retinoic acid-responsive element binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006766 (vitamin metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0032526 (response to retinoic acid)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0044255 (cellular lipid metabolic process)
GO:0044419 (interspecies interaction between organisms)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia Retinoid_X_receptor_alpha

Target Cross References - Protein

canSAR P19793
Human Protein Atlas ENSG00000186350
IntAct P19793
IUPHAR 610 (Retinoid X receptor-Alpha;)
PharmGKB PA34890
Reactome REACT_15380 (Diabetes pathways.)
REACT_22258 (Metabolism of lipids and lipoproteins.)
REACT_71 (Gene Expression.)
UniProt P19793 Q2NL52 Q2V504

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
IPR021780 (DUF3345.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF11825 (DUF3345)

Target Cross References - Structure

PDBe 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...
CREDO 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ More...
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