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Target Report Card

Target Name and Classification

Target ID CHEMBL2060
Preferred Name Lipoprotein lipase
Synonyms LIPD | LPL | LPL | Lipoprotein lipase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Lipoprotein lipase SINGLE PROTEIN P06858

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175445
Ensembl ENSG00000175445
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0031012 (extracellular matrix)
GO:0031225 (anchored component of membrane)
GO:0034361 (very-low-density lipoprotein particle)
GO:0042627 (chylomicron)
GO Molecular Function GO:0004465 (lipoprotein lipase activity)
GO:0004620 (phospholipase activity)
GO:0004806 (triglyceride lipase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0016787 (hydrolase activity)
GO:0017129 (triglyceride binding)
GO:0034185 (apolipoprotein binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006641 (triglyceride metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0009409 (response to cold)
GO:0009749 (response to glucose)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010886 (positive regulation of cholesterol storage)
GO:0010890 (positive regulation of sequestering of triglyceride)
GO:0016042 (lipid catabolic process)
GO:0019432 (triglyceride biosynthetic process)
GO:0019433 (triglyceride catabolic process)
GO:0034371 (chylomicron remodeling)
GO:0034372 (very-low-density lipoprotein particle remodeling)
GO:0042493 (response to drug)
GO:0042632 (cholesterol homeostasis)
GO:0050729 (positive regulation of inflammatory response)
GO:0051004 (regulation of lipoprotein lipase activity)
GO:0055096 (low-density lipoprotein particle mediated signaling)
GO:0070328 (triglyceride homeostasis)
GO:0090197 (positive regulation of chemokine secretion)
Wikipedia Lipoprotein_lipase

Target Cross References - Protein

canSAR P06858
CGD Lipoprotein lipase deficiency; Combined hyperlipidemia, familial; Hyperlipoproteinemia, type I
Human Protein Atlas ENSG00000175445
IntAct P06858
Open Targets ENSG00000175445
PharmGKB PA232
Reactome R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-8963889 (Assembly of active LPL and LIPC lipase complexes.)
R-HSA-8963901 (Chylomicron remodeling.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt B2R5T9 P06858 Q16282 Q16283 Q96FC4

Target Cross References - Domain

InterPro IPR000734 (TAG_lipase.)
IPR001024 (PLAT/LH2_dom.)
IPR002330 (Lipo_Lipase.)
IPR013818 (Lipase/vitellogenin.)
IPR016272 (Lipase_LIPH.)
IPR029058 (AB_hydrolase.)
IPR033906 (Lipase_N.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00151 (Lipase)
PF01477 (PLAT)