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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2058
Target Type SINGLE PROTEIN
Preferred Name B-lymphocyte antigen CD20
Synonyms B-lymphocyte antigen CD20 | B-lymphocyte surface antigen B1 | Bp35 | CD20 | CD_antigen=CD20 | Leukocyte surface antigen Leu-16 | MS4A1 | Membrane-spanning 4-domains subfamily A member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > cd20 ca2+ channel family

Target Components

Component Description Relationship Accession
B-lymphocyte antigen CD20 SINGLE PROTEIN P11836

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201606 IBRITUMOMAB TIUXETAN B-lymphocyte antigen CD20 binding agent 4 Other PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL1201604 TOSITUMOMAB B-lymphocyte antigen CD20 inhibitor 4 FDA
CHEMBL1201576 RITUXIMAB B-lymphocyte antigen CD20 inhibitor 4 DailyMed
CHEMBL1201836 OFATUMUMAB B-lymphocyte antigen CD20 inhibitor 4 DailyMed
CHEMBL1743048 OBINUTUZUMAB B-lymphocyte antigen CD20 inhibitor 4 FDA PubMed
CHEMBL2108041 OCRELIZUMAB B-lymphocyte antigen CD20 other 4 PubMed
CHEMBL2108667 YTTRIUM Y 90 IBRITUMOMAB TIUXETAN B-lymphocyte antigen CD20 binding agent 4 DailyMed
CHEMBL2108354 UBLITUXIMAB B-lymphocyte antigen CD20 other 3 PubMed
CHEMBL1743088 VELTUZUMAB B-lymphocyte antigen CD20 inhibitor 2 PubMed PubMed
CHEMBL2109348 LFB-R603 B-lymphocyte antigen CD20 cross-linking agent 1 PubMed
CHEMBL2109351 FBT-A05 B-lymphocyte antigen CD20 cross-linking agent 1 PubMed
CHEMBL2109665 OCARATUZUMAB B-lymphocyte antigen CD20 inhibitor 1 PubMed
CHEMBL3833304 TOSITUMOMAB 131I B-lymphocyte antigen CD20 binding agent 0 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156738
Ensembl ENSG00000156738
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0023026 (MHC class II protein complex binding)
GO Biological Process GO:0006959 (humoral immune response)
GO:0042100 (B cell proliferation)
GO:0042113 (B cell activation)
Wikipedia CD20

Target Cross References - Protein

canSAR P11836
CGD Immunodeficiency, common variable, 5
Human Protein Atlas ENSG00000156738
IntAct P11836
Guide to Pharmacology 2628
MICAD NBK23236 (CD20 antigen on B-cell non-Hodgkins lymphoma)
NBK23253 (CD20 antigen on B-cell non-Hodgkins lymphoma)
Open Targets ENSG00000156738
PharmGKB PA31111
UniProt A6NMS4 B4DT24 P08984 P11836 Q13963

Target Cross References - Domain

InterPro IPR007237 (CD20-like.)
IPR030417 (MS4A.)
IPR030418 (MS4A1.)
Pfam PF04103 (CD20)

Target Cross References - Structure

PDBe 2OSL 3BKY 3PP4
CREDO 2OSL 3BKY 3PP4
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