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Target Report Card

Target Name and Classification

Target ID CHEMBL2056
Preferred Name Dopamine D1 receptor
Synonyms D(1A) dopamine receptor | DRD1 | Dopamine D1 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1A) dopamine receptor SINGLE PROTEIN P21728

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111341 Dopamine D1 and D2 receptor SELECTIVITY GROUP
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1026 FENOLDOPAM MESYLATE Dopamine D1 receptor agonist 4 DailyMed
CHEMBL1200843 METHYLERGONOVINE MALEATE Dopamine D1 receptor antagonist 4 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184845
Ensembl ENSG00000184845
GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031513 (nonmotile primary cilium)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043679 (axon terminus)
GO:0044326 (dendritic spine neck)
GO:0044327 (dendritic spine head)
GO:0060170 (ciliary membrane)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0019903 (protein phosphatase binding)
GO:0031701 (angiotensin receptor binding)
GO:0031750 (D3 dopamine receptor binding)
GO:0032403 (protein complex binding)
GO:0035240 (dopamine binding)
GO:0046982 (protein heterodimerization activity)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001661 (conditioned taste aversion)
GO:0001662 (behavioral fear response)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006606 (protein import into nucleus)
GO:0006886 (intracellular protein transport)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007416 (synapse assembly)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007617 (mating behavior)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0010243 (response to organonitrogen compound)
GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
GO:0014002 (astrocyte development)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0019228 (neuronal action potential)
GO:0019229 (regulation of vasoconstriction)
GO:0019722 (calcium-mediated signaling)
GO:0021542 (dentate gyrus development)
GO:0021756 (striatum development)
GO:0021766 (hippocampus development)
GO:0021769 (orbitofrontal cortex development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0030335 (positive regulation of cell migration)
GO:0030336 (negative regulation of cell migration)
GO:0030432 (peristalsis)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0032094 (response to food)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032869 (cellular response to insulin stimulus)
GO:0035094 (response to nicotine)
GO:0035106 (operant conditioning)
GO:0035176 (social behavior)
GO:0036276 (response to antidepressant)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042220 (response to cocaine)
GO:0042311 (vasodilation)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0042711 (maternal behavior)
GO:0043200 (response to amino acid)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043269 (regulation of ion transport)
GO:0043278 (response to morphine)
GO:0045471 (response to ethanol)
GO:0045838 (positive regulation of membrane potential)
GO:0046323 (glucose import)
GO:0046959 (habituation)
GO:0046960 (sensitization)
GO:0048148 (behavioral response to cocaine)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048545 (response to steroid hormone)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051584 (regulation of dopamine uptake involved in synaptic transmission)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060134 (prepulse inhibition)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0071456 (cellular response to hypoxia)
GO:0071870 (cellular response to catecholamine stimulus)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:2000253 (positive regulation of feeding behavior)
Wikipedia Dopamine_receptor_D1

Target Cross References - Protein

canSAR P21728
Human Protein Atlas ENSG00000184845
Guide to Pharmacology 214
MICAD NBK23009 (D1 dopamine receptors)
NBK23252 (Dopamine D1 receptor)
Open Targets ENSG00000184845
PharmGKB PA147
Pharos P21728 (Tclin)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B2RA44 P21728 Q4QRJ0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001413 (Dopamine_D1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)