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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL205
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase II
Synonyms CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 | Carbonic anhydrase C | Carbonic anhydrase II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 2 SINGLE PROTEIN P00918

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY
CHEMBL2096906 Carbonic anhydrases; II & IX SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL17 DICHLORPHENAMIDE Carbonic anhydrase II inhibitor 4 PubMed
CHEMBL19 METHAZOLAMIDE Carbonic anhydrase II inhibitor 4 DailyMed PubMed
CHEMBL20 ACETAZOLAMIDE Carbonic anhydrase II inhibitor 4 PubMed
CHEMBL220491 BRINZOLAMIDE Carbonic anhydrase II inhibitor 4 DailyMed
CHEMBL220492 TOPIRAMATE Carbonic anhydrase II inhibitor 4 DailyMed PubMed
CHEMBL1200814 ACETAZOLAMIDE SODIUM Carbonic anhydrase II inhibitor 4 PubMed
CHEMBL1201162 DORZOLAMIDE HYDROCHLORIDE Carbonic anhydrase II inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104267
Ensembl ENSG00000104267
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030424 (axon)
GO:0043209 (myelin sheath)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004064 (arylesterase activity)
GO:0004089 (carbonate dehydratase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001822 (kidney development)
GO:0002009 (morphogenesis of an epithelium)
GO:0006730 (one-carbon metabolic process)
GO:0009268 (response to pH)
GO:0010033 (response to organic substance)
GO:0010043 (response to zinc ion)
GO:0015670 (carbon dioxide transport)
GO:0015701 (bicarbonate transport)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0032849 (positive regulation of cellular pH reduction)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0043627 (response to estrogen)
GO:0044070 (regulation of anion transport)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0045780 (positive regulation of bone resorption)
GO:0046903 (secretion)
GO:0048545 (response to steroid hormone)
GO:0051453 (regulation of intracellular pH)
GO:0071498 (cellular response to fluid shear stress)
GO:2001150 (positive regulation of dipeptide transmembrane transport)
GO:2001225 (regulation of chloride transport)
Wikipedia Carbonic_anhydrase_II

Target Cross References - Protein

canSAR P00918
CGD Osteopetrosis, autosomal recessive 3, with renal tubular acidosis
Human Protein Atlas ENSG00000104267
IntAct P00918
Open Targets ENSG00000104267
PharmGKB PA25989
Reactome R-HSA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-HSA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt B2R7G8 P00918 Q6FI12 Q96ET9

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018443 (CA2.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL
1CAM 1CAN 1CAO 1CAY 1CAZ 1CCS 1CCT 1CCU 1CIL 1CIM 1CIN 1CNB 1CNC 1CNG 1CNH 1CNI 1CNJ 1CNK 1CNW 1CNX 1CNY 1CRA 1CVA 1CVB 1CVC 1CVD 1CVE 1CVF 1CVH 1DCA 1DCB 1EOU 1F2W 1FQL 1FQM 1FQN 1FQR 1FR4 1FR7 1FSN 1FSQ 1FSR 1G0E 1G0F 1G1D 1G3Z 1G45 1G46 1G48 1G4J 1G4O 1G52 1G53 1G54 1H4N 1H9N 1H9Q 1HCA 1HEA 1HEB 1HEC 1HED 1HVA 1I8Z 1I90 1I91 1I9L 1I9M 1I9N 1I9O 1I9P 1I9Q 1IF4 1IF5 1IF6 1IF7 1IF8 1IF9 1KWQ 1KWR 1LG5 1LG6 1LGD 1LUG 1LZV 1MOO 1MUA 1OKL 1OKM 1OKN 1OQ5 1RAY 1RAZ 1RZA 1RZB 1RZC 1RZD 1RZE 1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9 1THK 1TTM 1UGA 1UGB 1UGC 1UGD 1UGE 1UGF 1UGG 1XEG 1XEV 1XPZ 1XQ0 1YDA 1YDB 1YDC 1YDD 1YO0 1YO1 1YO2 1Z9Y 1ZE8 1ZFK 1ZFQ 1ZGE 1ZGF 1ZH9 1ZSA 1ZSB 1ZSC 2ABE 2AW1 2AX2 2CA2 2CBA 2CBB 2CBC 2CBD 2CBE 2EU2 2EU3 2EZ7 2F14 2FMG 2FMZ 2FNK 2FNM 2FNN 2FOQ 2FOS 2FOU 2FOV 2GD8 2GEH 2H15 2H4N 2HD6 2HKK 2HL4 2HNC 2HOC 2ILI 2NNG 2NNO 2NNS 2NNV 2NWO 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT 2O4Z 2OSF 2OSM 2POU 2POV 2POW 2Q1B 2Q1Q 2Q38 2QO8 2QOA 2QP6 2VVA 2VVB 2WD2 2WD3 2WEG 2WEH 2WEJ 2WEO 2X7S 2X7T 2X7U 3B4F 3BET 3BL0 3BL1 3C7P 3CA2 3CAJ 3CYU 3D8W 3D92 3D93 3D9Z 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 3DD8 3DV7 3DVB 3DVC 3DVD 3EFI 3EFT 3F4X 3F8E 3FFP 3GZ0 3HFP 3HKN 3HKQ 3HKT 3HKU 3HLJ 3HS4 3IBI 3IBL 3IBN 3IBU 3IEO 3IGP 3K2F 3K34 3K7K 3KIG 3KNE 3KOI 3KOK 3KON 3KS3 3KWA 3L14 3M04 3M14 3M1J 3M1K 3M1Q 3M1W 3M2N 3M2X 3M2Y 3M2Z 3M3X 3M40 3M5E 3M5S 3M5T 3M67 3M96 3M98 3MHC 3MHI 3MHL 3MHM 3MHO 3ML2 3MMF 3MNA 3MNH 3MNI 3MNJ 3MNK 3MNU 3MWO 3MYQ 3MZC 3N0N 3N2P 3N3J 3N4B 3NB5 3NI5 3NJ9 3OIK 3OIL 3OIM 3OKU 3OKV 3OY0 3OYQ 3OYS 3P3H 3P3J 3P44 3P4V 3P55 3P58 3P5A 3P5L 3PJJ 3PO6 3PYK 3QYK 3R16 3R17 3RG3 3RG4 3RGE 3RJ7 3RLD 3RYJ 3RYV 3RYX 3RYY 3RYZ 3RZ0 3RZ1 3RZ5 3RZ7 3RZ8 3S71 3S72 3S73 3S74 3S75 3S76 3S77 3S78 3S8X 3S9T 3SAP 3SAX 3SBH 3SBI 3T5U 3T5Z 3T82 3T83 3T84 3T85 3TVN 3TVO 3U3A 3U45 3U47 3U7C 3V2J 3V2M 3V3F 3V3G 3V3H 3V3I 3V3J 3V5G 3V7X 3VBD 3ZP9 4BCW 4BF1 4BF6 4CA2 4CAC 4CQ0 4DZ7 4DZ9 4E3D 4E3F 4E3G 4E3H 4E49 4E4A 4E5Q 4FIK 4FL7 4FPT 4FRC 4FU5 4FVN 4FVO 4GL1 4HBA 4HEW 4HEY 4HEZ 4HF3 4HT0 4IDR 4ILX 4ITO 4ITP 4IWZ 4JS6 4JSA 4JSS 4JSW 4JSZ 4K0S 4K0T 4K0Z 4K13 4K1Q 4KAP 4KNI 4KNJ 4KUV 4KUW 4KUY 4KV0 4L5U 4L5V 4L5W 4LHI 4LP6 4M2R 4M2U 4M2V 4M2W 4MDG 4MDL 4MDM 4MLT 4MLX 4MO8 4MTY 4N0X 4N16 4PQ7 4PXX 4PYX 4PYY 4PZH 4Q06 4Q07 4Q08 4Q09 4Q6D 4Q6E 4Q78 4Q7P 4Q7S 4Q7V 4Q7W 4Q81 4Q83 4Q87 4Q8X 4Q8Y 4Q8Z 4Q90 4Q99 4Q9Y 4QEF 4QIY 4QJM 4QK1 4QK2 4QK3 4QSA 4QSB 4QSI 4QTL 4QY3 4R59 4R5A 4R5B 4RFC 4RFD 4RH2 4RIU 4RIV 4RN4 4RUX 4RUY 4RUZ 4WL4 4WW6 4XE1 4YGJ 4YGK 4YGL 4YGN 4YVY 4YWP 4YX4 4YXI 4YXO 4YXU 4YYT 4Z0Q 4Z1E 4Z1J 4Z1K 4Z1N 4ZAO 4ZWI 4ZWX 4ZWY 4ZWZ 4ZX0 4ZX1 5AMD 5AMG 5AML 5BNL 5BRU 5BRV 5BRW 5BYI 5CA2 5CAC 5CLU 5E28 5E2K 5E2R 5E2S 5EH5 5EH7 5EH8 5EHV 5EHW 5EKH 5EKJ 5EKM 5FLO 5FLP 5FLQ 5FLR 5FLS 5FLT 5FNG 5FNH 5FNI 5FNJ 5FNK 5FNM 6CA2 7CA2 8CA2 9CA2
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CREDO 12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL
1CAM 1CAN 1CAO 1CAY 1CAZ 1CCS 1CCT 1CCU 1CIL 1CIM 1CIN 1CNB 1CNC 1CNG 1CNH 1CNI 1CNJ 1CNK 1CNW 1CNX 1CNY 1CRA 1CVA 1CVB 1CVC 1CVD 1CVE 1CVF 1CVH 1DCA 1DCB 1EOU 1F2W 1FQL 1FQM 1FQN 1FQR 1FR4 1FR7 1FSN 1FSQ 1FSR 1G0E 1G0F 1G1D 1G3Z 1G45 1G46 1G48 1G4J 1G4O 1G52 1G53 1G54 1H4N 1H9N 1H9Q 1HCA 1HEA 1HEB 1HEC 1HED 1HVA 1I8Z 1I90 1I91 1I9L 1I9M 1I9N 1I9O 1I9P 1I9Q 1IF4 1IF5 1IF6 1IF7 1IF8 1IF9 1KWQ 1KWR 1LG5 1LG6 1LGD 1LUG 1LZV 1MOO 1MUA 1OKL 1OKM 1OKN 1OQ5 1RAY 1RAZ 1RZA 1RZB 1RZC 1RZD 1RZE 1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9 1THK 1TTM 1UGA 1UGB 1UGC 1UGD 1UGE 1UGF 1UGG 1XEG 1XEV 1XPZ 1XQ0 1YDA 1YDB 1YDC 1YDD 1YO0 1YO1 1YO2 1Z9Y 1ZE8 1ZFK 1ZFQ 1ZGE 1ZGF 1ZH9 1ZSA 1ZSB 1ZSC 2ABE 2AW1 2AX2 2CA2 2CBA 2CBB 2CBC 2CBD 2CBE 2EU2 2EU3 2EZ7 2F14 2FMG 2FMZ 2FNK 2FNM 2FNN 2FOQ 2FOS 2FOU 2FOV 2GD8 2GEH 2H15 2H4N 2HD6 2HKK 2HL4 2HNC 2HOC 2ILI 2NNG 2NNO 2NNS 2NNV 2NWO 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT 2O4Z 2OSF 2OSM 2POU 2POV 2POW 2Q1B 2Q1Q 2Q38 2QO8 2QOA 2QP6 2VVA 2VVB 2WD2 2WD3 2WEG 2WEH 2WEJ 2WEO 2X7S 2X7T 2X7U 3B4F 3BET 3BL0 3BL1 3C7P 3CA2 3CAJ 3CYU 3D8W 3D92 3D93 3D9Z 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 3DD8 3DV7 3DVB 3DVC 3DVD 3EFI 3EFT 3F4X 3F8E 3FFP 3GZ0 3HFP 3HKN 3HKQ 3HKT 3HKU 3HLJ 3HS4 3IBI 3IBL 3IBN 3IBU 3IEO 3IGP 3K2F 3K34 3K7K 3KIG 3KNE 3KOI 3KOK 3KON 3KS3 3KWA 3L14 3M04 3M14 3M1J 3M1K 3M1Q 3M1W 3M2N 3M2X 3M2Y 3M2Z 3M3X 3M40 3M5E 3M5S 3M5T 3M67 3M96 3M98 3MHC 3MHI 3MHL 3MHM 3MHO 3ML2 3MMF 3MNA 3MNH 3MNI 3MNJ 3MNK 3MNU 3MWO 3MYQ 3MZC 3N0N 3N2P 3N3J 3N4B 3NB5 3NI5 3NJ9 3OIK 3OIL 3OIM 3OKU 3OKV 3OY0 3OYQ 3OYS 3P3H 3P3J 3P44 3P4V 3P55 3P58 3P5A 3P5L 3PJJ 3PO6 3PYK 3QYK 3R16 3R17 3RG3 3RG4 3RGE 3RJ7 3RLD 3RYJ 3RYV 3RYX 3RYY 3RYZ 3RZ0 3RZ1 3RZ5 3RZ7 3RZ8 3S71 3S72 3S73 3S74 3S75 3S76 3S77 3S78 3S8X 3S9T 3SAP 3SAX 3SBH 3SBI 3T5U 3T5Z 3T82 3T83 3T84 3T85 3TVN 3TVO 3U3A 3U45 3U47 3U7C 3V2J 3V2M 3V3F 3V3G 3V3H 3V3I 3V3J 3V5G 3V7X 3VBD 3ZP9 4BCW 4BF1 4BF6 4CA2 4CAC 4CQ0 4DZ7 4DZ9 4E3D 4E3F 4E3G 4E3H 4E49 4E4A 4E5Q 4FIK 4FL7 4FPT 4FRC 4FU5 4FVN 4FVO 4GL1 4HBA 4HEW 4HEY 4HEZ 4HF3 4HT0 4IDR 4ILX 4ITO 4ITP 4IWZ 4JS6 4JSA 4JSS 4JSW 4JSZ 4K0S 4K0T 4K0Z 4K13 4K1Q 4KAP 4KNI 4KNJ 4KUV 4KUW 4KUY 4KV0 4L5U 4L5V 4L5W 4LHI 4LP6 4M2R 4M2U 4M2V 4M2W 4MDG 4MDL 4MDM 4MLT 4MLX 4MO8 4MTY 4N0X 4N16 4PQ7 4PXX 4PYX 4PYY 4PZH 4Q06 4Q07 4Q08 4Q09 4Q6D 4Q6E 4Q78 4Q7P 4Q7S 4Q7V 4Q7W 4Q81 4Q83 4Q87 4Q8X 4Q8Y 4Q8Z 4Q90 4Q99 4Q9Y 4QEF 4QIY 4QJM 4QK1 4QK2 4QK3 4QSA 4QSB 4QSI 4QTL 4QY3 4R59 4R5A 4R5B 4RFC 4RFD 4RH2 4RIU 4RIV 4RN4 4RUX 4RUY 4RUZ 4WL4 4WW6 4XE1 4YGJ 4YGK 4YGL 4YGN 4YVY 4YWP 4YX4 4YXI 4YXO 4YXU 4YYT 4Z0Q 4Z1E 4Z1J 4Z1K 4Z1N 4ZAO 4ZWI 4ZWX 4ZWY 4ZWZ 4ZX0 4ZX1 5AMD 5AMG 5AML 5BNL 5BRU 5BRV 5BRW 5BYI 5CA2 5CAC 5CLU 5E28 5E2K 5E2R 5E2S 5EH5 5EH7 5EH8 5EHV 5EHW 5EKH 5EKJ 5EKM 5FLO 5FLP 5FLQ 5FLR 5FLS 5FLT 5FNG 5FNH 5FNI 5FNJ 5FNK 5FNM 6CA2 7CA2 8CA2 9CA2
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