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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL205
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase II
Synonyms CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 | Carbonic anhydrase C | Carbonic anhydrase II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 2 SINGLE PROTEIN P00918

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY
CHEMBL2096906 Carbonic anhydrases; II & IX SELECTIVITY GROUP

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL20 ACETAZOLAMIDE Carbonic anhydrase II inhibitor PubMed
CHEMBL1200814 ACETAZOLAMIDE SODIUM Carbonic anhydrase II inhibitor PubMed
CHEMBL220491 BRINZOLAMIDE Carbonic anhydrase II inhibitor DailyMed
CHEMBL17 DICHLORPHENAMIDE Carbonic anhydrase II inhibitor PubMed
CHEMBL1201162 DORZOLAMIDE HYDROCHLORIDE Carbonic anhydrase II inhibitor DailyMed
CHEMBL19 METHAZOLAMIDE Carbonic anhydrase II inhibitor DailyMed PubMed
CHEMBL220492 TOPIRAMATE Carbonic anhydrase II inhibitor DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104267
Ensembl ENSG00000104267
GO Cellular Component GO:0045177 (apical part of cell)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006730 (one-carbon metabolic process)
Wikipedia Carbonic_anhydrase_II

Target Cross References - Protein

canSAR P00918
CGD Osteopetrosis, autosomal recessive 3, with renal tubular acidosis
Human Protein Atlas ENSG00000104267
IntAct P00918
PharmGKB PA25989
UniProt B2R7G8 P00918 Q6FI12 Q96ET9

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a-class_cat.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018440 (Carbonic_anhydrase_CA2.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL More...
CREDO 12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL More...
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