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Target Report Card

Target Name and Classification

Target ID CHEMBL2049
Preferred Name Oxytocin receptor
Synonyms OT-R | OXTR | Oxytocin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > vasopressin and oxytocin receptor

Target Components

Component Description Relationship Accession
Oxytocin receptor SINGLE PROTEIN P30559

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL395429 OXYTOCIN Oxytocin receptor agonist 4 DailyMed FDA ISBN
CHEMBL429736 RETOSIBAN Oxytocin receptor antagonist 3 PubMed
CHEMBL419667 RELCOVAPTAN Oxytocin receptor antagonist 2 PubMed PubMed
CHEMBL2037511 EPELSIBAN Oxytocin receptor antagonist 2 PubMed PubMed
CHEMBL2218898 BARUSIBAN Oxytocin receptor antagonist 2 PubMed PubMed
CHEMBL3545167 FE 202767 Oxytocin receptor agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180914
Ensembl ENSG00000180914
GO Cellular Component GO:0005622 (intracellular)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005902 (microvillus)
GO:0005913 (cell-cell adherens junction)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004990 (oxytocin receptor activity)
GO:0005000 (vasopressin receptor activity)
GO:0017046 (peptide hormone binding)
GO:0042277 (peptide binding)
GO Biological Process GO:0001967 (suckling behavior)
GO:0001975 (response to amphetamine)
GO:0001992 (regulation of systemic arterial blood pressure by vasopressin)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007507 (heart development)
GO:0007565 (female pregnancy)
GO:0007595 (lactation)
GO:0007613 (memory)
GO:0010701 (positive regulation of norepinephrine secretion)
GO:0014070 (response to organic cyclic compound)
GO:0021537 (telencephalon development)
GO:0030431 (sleep)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0032355 (response to estradiol)
GO:0032570 (response to progesterone)
GO:0032870 (cellular response to hormone stimulus)
GO:0034059 (response to anoxia)
GO:0034097 (response to cytokine)
GO:0035176 (social behavior)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042711 (maternal behavior)
GO:0042713 (sperm ejaculation)
GO:0042755 (eating behavior)
GO:0043434 (response to peptide hormone)
GO:0044058 (regulation of digestive system process)
GO:0044849 (estrous cycle)
GO:0045777 (positive regulation of blood pressure)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048545 (response to steroid hormone)
GO:0048565 (digestive tract development)
GO:0051965 (positive regulation of synapse assembly)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060137 (maternal process involved in parturition)
GO:0060406 (positive regulation of penile erection)
GO:0060455 (negative regulation of gastric acid secretion)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070474 (positive regulation of uterine smooth muscle contraction)
GO:1901652 (response to peptide)
Wikipedia Oxytocin_receptor

Target Cross References - Protein

canSAR P30559
Human Protein Atlas ENSG00000180914
Guide to Pharmacology 369
Open Targets ENSG00000180914
PharmGKB PA32858
Pharos P30559 (Tclin)
Reactome R-HSA-388479 (Vasopressin-like receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P30559 Q15071

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001817 (Vasoprsn_rcpt.)
IPR002062 (Oxytocn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)