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Target Report Card

Target Name and Classification

Target ID CHEMBL2048
Preferred Name Fibrinogen beta chain
Synonyms FGB | Fibrinogen beta chain | Fibrinopeptide B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Fibrinogen beta chain SINGLE PROTEIN P02675

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171564
Ensembl ENSG00000171564
GO Cellular Component GO:0005576 (extracellular region)
GO:0005577 (fibrinogen complex)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0031091 (platelet alpha granule)
GO:0031093 (platelet alpha granule lumen)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005198 (structural molecule activity)
GO:0005515 (protein binding)
GO:0030674 (protein binding, bridging)
GO:0050839 (cell adhesion molecule binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002576 (platelet degranulation)
GO:0007160 (cell-matrix adhesion)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0030168 (platelet activation)
GO:0030198 (extracellular matrix organization)
GO:0031639 (plasminogen activation)
GO:0034116 (positive regulation of heterotypic cell-cell adhesion)
GO:0042730 (fibrinolysis)
GO:0043152 (induction of bacterial agglutination)
GO:0043623 (cellular protein complex assembly)
GO:0044320 (cellular response to leptin stimulus)
GO:0045087 (innate immune response)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045921 (positive regulation of exocytosis)
GO:0050714 (positive regulation of protein secretion)
GO:0051258 (protein polymerization)
GO:0051592 (response to calcium ion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070527 (platelet aggregation)
GO:0071347 (cellular response to interleukin-1)
GO:0072378 (blood coagulation, fibrin clot formation)
GO:0090277 (positive regulation of peptide hormone secretion)
GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
Wikipedia Fibrinogen_beta_chain

Target Cross References - Protein

canSAR P02675
CGD Afibrinogenemia, congenital; Dysfibrinogenemia, beta type
Human Protein Atlas ENSG00000171564
IntAct P02675
Open Targets ENSG00000171564
PharmGKB PA163
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-HSA-372708 (p130Cas linkage to MAPK signaling for integrins.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5686938 (Regulation of TLR by endogenous ligand.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
UniProt A0JLR9 B2R7G3 P02675 Q32Q65 Q3KPF2

Target Cross References - Domain

InterPro IPR002181 (Fibrinogen_a/b/g_C_dom.)
IPR012290 (Fibrinogen_a/b/g_coil_dom.)
IPR014715 (Fibrinogen_a/b/g_C_2.)
IPR014716 (Fibrinogen_a/b/g_C_1.)
IPR020837 (Fibrinogen_CS.)
Pfam PF00147 (Fibrinogen_C)
PF08702 (Fib_alpha)

Target Cross References - Structure

PDBe 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX More...
CREDO 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX More...