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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2041
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase receptor RET
Synonyms CDHF12 | CDHR16 | Cadherin family member 12 | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment | PTC | Proto-oncogene c-Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | RET | RET51 | Soluble RET kinase fragment
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase ret family

Target Components

Component Description Relationship Accession
Proto-oncogene tyrosine-protein kinase receptor Ret SINGLE PROTEIN P07949

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1946170 REGORAFENIB Tyrosine-protein kinase receptor RET inhibitor Expert
CHEMBL1200485 SORAFENIB TOSYLATE Tyrosine-protein kinase receptor RET inhibitor FDA
CHEMBL1567 SUNITINIB MALATE Tyrosine-protein kinase receptor RET inhibitor DailyMed
CHEMBL24828 VANDETANIB Tyrosine-protein kinase receptor RET inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165731
Ensembl ENSG00000165731
GO Cellular Component GO:0016021 (integral to membrane)
GO Molecular Function GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005509 (calcium ion binding)
GO:0005524 (ATP binding)
GO:0016563 (transcription activator activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007156 (homophilic cell adhesion)
GO:0007497 (posterior midgut development)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0072300 (positive regulation of metanephric glomerulus development)
Wikipedia RET_proto-oncogene

Target Cross References - Protein

canSAR P07949
CGD Multiple endocrine neoplasia, type IIA; Multiple endocrine neoplasia IIB; Medullary thyroid carcinoma, familial; Pheochromocytoma; Hirschsprung disease, susceptibility to
Human Protein Atlas ENSG00000165731
Guide to Pharmacology 2185 (ret proto-oncogene)
PharmGKB PA34335
UniProt A8K6Z2 P07949 Q15250 Q9BTB0 Q9H4A2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR002126 (Cadherin.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015919 (Cadherin-like.)
IPR016249 (Tyr_prot_kinase_Ret_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00028 (Cadherin)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
CREDO 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
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