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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2040
Preferred Name T-cell surface antigen CD2
Synonyms CD2 | CD_antigen=CD2 | Erythrocyte receptor | LFA-2 | LFA-3 receptor | Rosette receptor | SRBC | T-cell surface antigen CD2 | T-cell surface antigen T11/Leu-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
T-cell surface antigen CD2 SINGLE PROTEIN P06729

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885600 Lymphocyte function-associated antigen 3/T-cell surface antigen CD2 PROTEIN-PROTEIN INTERACTION

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201571 ALEFACEPT T-cell surface antigen CD2 inhibitor 4 DailyMed FDA
CHEMBL2108742 SIPLIZUMAB T-cell surface antigen CD2 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116824
Ensembl ENSG00000116824
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0009897 (external side of plasma membrane)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0046658 (anchored component of plasma membrane)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001766 (membrane raft polarization)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0007166 (cell surface receptor signaling pathway)
GO:0030101 (natural killer cell activation)
GO:0030887 (positive regulation of myeloid dendritic cell activation)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0042110 (T cell activation)
GO:0045580 (regulation of T cell differentiation)
GO:0050900 (leukocyte migration)
GO:0098609 (cell-cell adhesion)
GO:1902715 (positive regulation of interferon-gamma secretion)
GO:2000484 (positive regulation of interleukin-8 secretion)
Wikipedia CD2

Target Cross References - Protein

canSAR P06729
Human Protein Atlas ENSG00000116824
IntAct P06729
Open Targets ENSG00000116824
PharmGKB PA26198
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
UniProt P06729 Q96TE5

Target Cross References - Domain

InterPro IPR008424 (Ig_C2-set.)
IPR013106 (Ig_V-set.)
IPR013783 (Ig-like_fold.)
IPR015632 (CD2.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF05790 (C2-set)
PF07686 (V-set)

Target Cross References - Structure

PDBe 1HNF 1QA9 2J6O 2J7I