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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL204
Preferred Name Thrombin
Synonyms Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Thrombin heavy chain | Thrombin light chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Prothrombin SINGLE PROTEIN P00734

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111477 Thrombin and coagulation factor VII SELECTIVITY GROUP
CHEMBL2111379 Thrombin and urokinase-type plasminogen activator SELECTIVITY GROUP
CHEMBL2096988 Thrombin & trypsin SELECTIVITY GROUP
CHEMBL2111401 Thrombin and coagulation factor X SELECTIVITY GROUP

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1166 ARGATROBAN Thrombin inhibitor DailyMed
CHEMBL2103749 BIVALIRUDIN Thrombin inhibitor DailyMed
CHEMBL1201662 DESIRUDIN Thrombin inhibitor DailyMed
CHEMBL1201666 LEPIRUDIN Thrombin inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180210
Ensembl ENSG00000180210
GO Cellular Component GO:0005615 (extracellular space)
GO:0005625 (soluble fraction)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008083 (growth factor activity)
GO:0070053 (thrombospondin receptor activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006508 (proteolysis)
GO:0006919 (activation of caspase activity)
GO:0006953 (acute-phase response)
GO:0007166 (cell surface receptor linked signaling pathway)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0007262 (STAT protein import into nucleus)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0010544 (negative regulation of platelet activation)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0030168 (platelet activation)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0042730 (fibrinolysis)
GO:0043687 (post-translational protein modification)
GO:0045861 (negative regulation of proteolysis)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:0050900 (leukocyte migration)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051480 (cytosolic calcium ion homeostasis)
GO:0051918 (negative regulation of fibrinolysis)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia Thrombin

Target Cross References - Protein

canSAR P00734
CGD Prothrombin deficiency, congenital; Thrombophilia due to thrombin defect
Human Protein Atlas ENSG00000180210
IntAct P00734
Guide to Pharmacology 2362 (coagulation factor II (thrombin))
PharmGKB PA157
Reactome REACT_14797 (Signaling by GPCR.)
REACT_15380 (Diabetes pathways.)
REACT_17015 (Metabolism of proteins.)
REACT_604 (Hemostasis.)
UniProt B2R7F7 B4E1A7 P00734 Q4QZ40 Q53H04 Q53H06 Q7Z7P3 Q9UCA1

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000294 (GLA_domain.)
IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR003966 (Peptidase_S1A_prothrombin.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR013806 (Kringle-like.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018056 (Kringle_CS.)
IPR018114 (Peptidase_S1/S6_AS.)
IPR018992 (Thrombin_light_chain.)
Pfam PF00051 (Kringle)
PF00089 (Trypsin)
PF00594 (Gla)
PF09396 (Thrombin_light)

Target Cross References - Structure

PDBe 1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX More...
CREDO 1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX More...