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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL204
Target Type SINGLE PROTEIN
Preferred Name Thrombin
Synonyms Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Thrombin heavy chain | Thrombin light chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Prothrombin SINGLE PROTEIN P00734

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096988 Thrombin & trypsin SELECTIVITY GROUP
CHEMBL2111401 Thrombin and coagulation factor X SELECTIVITY GROUP
CHEMBL2111477 Thrombin and coagulation factor VII SELECTIVITY GROUP
CHEMBL2111379 Thrombin and urokinase-type plasminogen activator SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1166 ARGATROBAN Thrombin inhibitor 4 DailyMed
CHEMBL1201666 LEPIRUDIN Thrombin inhibitor 4 DailyMed FDA
CHEMBL1201662 DESIRUDIN Thrombin inhibitor 4 DailyMed FDA
CHEMBL1615369 DABIGATRAN ETEXILATE MESYLATE Thrombin inhibitor 4 DailyMed
CHEMBL2103749 BIVALIRUDIN Thrombin inhibitor 4 DailyMed
CHEMBL48361 DABIGATRAN Thrombin inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180210
Ensembl ENSG00000180210
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0070053 (thrombospondin receptor activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0006953 (acute-phase response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007599 (hemostasis)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009611 (response to wounding)
GO:0010468 (regulation of gene expression)
GO:0010544 (negative regulation of platelet activation)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0014854 (response to inactivity)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0030168 (platelet activation)
GO:0030193 (regulation of blood coagulation)
GO:0030194 (positive regulation of blood coagulation)
GO:0030307 (positive regulation of cell growth)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0042730 (fibrinolysis)
GO:0044267 (cellular protein metabolic process)
GO:0045861 (negative regulation of proteolysis)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:0050900 (leukocyte migration)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:0051918 (negative regulation of fibrinolysis)
GO:0071260 (cellular response to mechanical stimulus)
GO:1900738 (positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia Thrombin

Target Cross References - Protein

canSAR P00734
CGD Prothrombin deficiency, congenital; Thrombophilia due to thrombin defect
Human Protein Atlas ENSG00000180210
IntAct P00734
Guide to Pharmacology 2362
Open Targets ENSG00000180210
PharmGKB PA157
Reactome R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-159740 (Gamma-carboxylation of protein precursors.)
R-HSA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-HSA-76009 (Platelet Aggregation (Plug Formation).)
UniProt B2R7F7 B4E1A7 P00734 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000294 (GLA_domain.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR003966 (Prothrombin/thrombin.)
IPR009003 (Peptidase_S1_PA.)
IPR013806 (Kringle-like.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018056 (Kringle_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR018992 (Thrombin_light_chain.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00051 (Kringle)
PF00089 (Trypsin)
PF00594 (Gla)
PF09396 (Thrombin_light)

Target Cross References - Structure

PDBe 1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX
1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DOJ 1DWB 1DWC 1DWD 1DWE 1DX5 1E0F 1EB1 1EOJ 1EOL 1FPC 1FPH 1G30 1G32 1G37 1GHV 1GHW 1GHX 1GHY 1GJ4 1GJ5 1H8D 1H8I 1HAG 1HAH 1HAI 1HAO 1HAP 1HBT 1HDT 1HGT 1HLT 1HUT 1HXE 1HXF 1IHS 1IHT 1JMO 1JOU 1JWT 1K21 1K22 1KTS 1KTT 1LHC 1LHD 1LHE 1LHF 1LHG 1MH0 1MU6 1MU8 1MUE 1NM6 1NO9 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1NT1 1NU7 1NU9 1NY2 1NZQ 1O0D 1O2G 1O5G 1OOK 1OYT 1P8V 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1RD3 1RIW 1SB1 1SFQ 1SG8 1SGI 1SHH 1SL3 1SR5 1T4U 1T4V 1TA2 1TA6 1TB6 1TBZ 1THP 1THR 1THS 1TMB 1TMT 1TMU 1TOM 1TQ0 1TQ7 1TWX 1UMA 1UVS 1VR1 1VZQ 1W7G 1WAY 1WBG 1XM1 1XMN 1YPE 1YPG 1YPJ 1YPK 1YPL 1YPM 1Z71 1Z8I 1Z8J 1ZGI 1ZGV 1ZRB 2A0Q 2A2X 2A45 2AFQ 2ANK 2ANM 2B5T 2BDY 2BVR 2BVS 2BVX 2BXT 2BXU 2C8W 2C8X 2C8Y 2C8Z 2C90 2C93 2CF8 2CF9 2CN0 2FEQ 2FES 2GDE 2GP9 2H9T 2HGT 2HNT 2HPP 2HPQ 2HWL 2JH0 2JH5 2JH6 2OD3 2PGB 2PGQ 2PKS 2PW8 2R2M 2THF 2UUF 2UUJ 2UUK 2V3H 2V3O 2ZC9 2ZDA 2ZDV 2ZF0 2ZFF 2ZFP 2ZFQ 2ZFR 2ZG0 2ZGB 2ZGX 2ZHE 2ZHF 2ZHQ 2ZHW 2ZI2 2ZIQ 2ZNK 2ZO3 3B23 3B9F 3BEF 3BEI 3BF6 3BIU 3BIV 3BV9 3C1K 3C27 3D49 3DA9 3DD2 3DHK 3DT0 3DUX 3E6P 3EE0 3EGK 3EQ0 3F68 3GIC 3GIS 3HAT 3HKJ 3HTC 3JZ1 3JZ2 3K65 3LDX 3LU9 3NXP 3P17 3P6Z 3P70 3PMH 3PO1 3QDZ 3QGN 3QLP 3QTO 3QTV 3QWC 3QX5 3R3G 3RLW 3RLY 3RM0 3RM2 3RML 3RMM 3RMN 3RMO 3S7H 3S7K 3SHA 3SHC 3SI3 3SI4 3SQE 3SQH 3SV2 3T5F 3TU7 3U69 3U8O 3U8R 3U8T 3U98 3U9A 3UTU 3UWJ 3VXE 4AX9 4AYV 4AYY 4AZ2 4BAH 4BAK 4BAM 4BAN 4BAO 4BAQ 4BOH 4CH2 4CH8 4DIH 4DII 4DT7 4DY7 4E05 4E06 4E7R 4H6S 4H6T 4HFP 4HTC 4HZH 4I7Y 4LOY 4LXB 4LZ1 4LZ4 4MLF 4N3L 4NZE 4NZQ 4O03 4RKJ 4RKO 4RN6 4THN 4UD9 4UDW 4UE7 4UEH 4UFD 4UFE 4UFF 4UFG 4YES 5A2M 5AF9 5AFY 5AFZ 5AHG 5CMX 5DO4 5E8E 5EDK 5EDM 5EW1 5EW2 5GDS 5JDU 5LUW 5LUY 7KME 8KME
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CREDO 1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX
1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DOJ 1DWB 1DWC 1DWD 1DWE 1DX5 1E0F 1EB1 1EOJ 1EOL 1FPC 1FPH 1G30 1G32 1G37 1GHV 1GHW 1GHX 1GHY 1GJ4 1GJ5 1H8D 1H8I 1HAG 1HAH 1HAI 1HAO 1HAP 1HBT 1HDT 1HGT 1HLT 1HUT 1HXE 1HXF 1IHS 1IHT 1JMO 1JOU 1JWT 1K21 1K22 1KTS 1KTT 1LHC 1LHD 1LHE 1LHF 1LHG 1MH0 1MU6 1MU8 1MUE 1NM6 1NO9 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1NT1 1NU7 1NU9 1NY2 1NZQ 1O0D 1O2G 1O5G 1OOK 1OYT 1P8V 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1RD3 1RIW 1SB1 1SFQ 1SG8 1SGI 1SHH 1SL3 1SR5 1T4U 1T4V 1TA2 1TA6 1TB6 1TBZ 1THP 1THR 1THS 1TMB 1TMT 1TMU 1TOM 1TQ0 1TQ7 1TWX 1UMA 1UVS 1VR1 1VZQ 1W7G 1WAY 1WBG 1XM1 1XMN 1YPE 1YPG 1YPJ 1YPK 1YPL 1YPM 1Z71 1Z8I 1Z8J 1ZGI 1ZGV 1ZRB 2A0Q 2A2X 2A45 2AFQ 2ANK 2ANM 2B5T 2BDY 2BVR 2BVS 2BVX 2BXT 2BXU 2C8W 2C8X 2C8Y 2C8Z 2C90 2C93 2CF8 2CF9 2CN0 2FEQ 2FES 2GDE 2GP9 2H9T 2HGT 2HNT 2HPP 2HPQ 2HWL 2JH0 2JH5 2JH6 2OD3 2PGB 2PGQ 2PKS 2PW8 2R2M 2THF 2UUF 2UUJ 2UUK 2V3H 2V3O 2ZC9 2ZDA 2ZDV 2ZF0 2ZFF 2ZFP 2ZFQ 2ZFR 2ZG0 2ZGB 2ZGX 2ZHE 2ZHF 2ZHQ 2ZHW 2ZI2 2ZIQ 2ZNK 2ZO3 3B23 3B9F 3BEF 3BEI 3BF6 3BIU 3BIV 3BV9 3C1K 3C27 3D49 3DA9 3DD2 3DHK 3DT0 3DUX 3E6P 3EE0 3EGK 3EQ0 3F68 3GIC 3GIS 3HAT 3HKJ 3HTC 3JZ1 3JZ2 3K65 3LDX 3LU9 3NXP 3P17 3P6Z 3P70 3PMH 3PO1 3QDZ 3QGN 3QLP 3QTO 3QTV 3QWC 3QX5 3R3G 3RLW 3RLY 3RM0 3RM2 3RML 3RMM 3RMN 3RMO 3S7H 3S7K 3SHA 3SHC 3SI3 3SI4 3SQE 3SQH 3SV2 3T5F 3TU7 3U69 3U8O 3U8R 3U8T 3U98 3U9A 3UTU 3UWJ 3VXE 4AX9 4AYV 4AYY 4AZ2 4BAH 4BAK 4BAM 4BAN 4BAO 4BAQ 4BOH 4CH2 4CH8 4DIH 4DII 4DT7 4DY7 4E05 4E06 4E7R 4H6S 4H6T 4HFP 4HTC 4HZH 4I7Y 4LOY 4LXB 4LZ1 4LZ4 4MLF 4N3L 4NZE 4NZQ 4O03 4RKJ 4RKO 4RN6 4THN 4UD9 4UDW 4UE7 4UEH 4UFD 4UFE 4UFF 4UFG 4YES 5A2M 5AF9 5AFY 5AFZ 5AHG 5CMX 5DO4 5E8E 5EDK 5EDM 5EW1 5EW2 5GDS 5JDU 5LUW 5LUY 7KME 8KME
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